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Radicicol (Monorden) is an antifungal antibiotic and a potent inhibitor of heat shock protein 90 (Hsp90), which leads to the degradation of Hsp90 by the proteasome by binding to its ATP-binding pocket. In addition, Radicicol inhibits the growth and proliferation of several tumor cell lines. It also has anti-malarial activity and acts as an inhibitor of adipose- and obesity-related proteins (FTO). Radicicol inhibits iNOS gene expression by blocking the p38 kinase signaling pathway and NF-kB/Rel
Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 μg | Inquiry | 35 days | |
1 mg | $178 | 35 days | |
5 mg | Inquiry | 35 days |
Description | Radicicol (Monorden) is an antifungal antibiotic and a potent inhibitor of heat shock protein 90 (Hsp90), which leads to the degradation of Hsp90 by the proteasome by binding to its ATP-binding pocket. In addition, Radicicol inhibits the growth and proliferation of several tumor cell lines. It also has anti-malarial activity and acts as an inhibitor of adipose- and obesity-related proteins (FTO). Radicicol inhibits iNOS gene expression by blocking the p38 kinase signaling pathway and NF-kB/Rel |
Targets&IC50 | HSP90:1 μM |
In vitro | Radicicol inhibits PDK1 activity with an IC50 value of 230 mM and PDK3 with an IC50 value of 400 μM.[1] |
In vivo | Methods: Radicicol (20 mg/kg/60 mg/kg, intraperitoneal injection, 2 doses, 1 h apart) was administered to mice to observe its inhibitory effect on (I/R) injury in mice. Results: Radicicol has a renal protective effect, improves renal ischemia-reperfusion (I/R) injury, and increases renal HSP70 mRNA and protein in mice with renal injury. [4] |
Alias | Monorden |
Molecular Weight | 364.78 |
Formula | C18H17ClO6 |
Cas No. | 12772-57-5 |
Smiles | C[C@@H]1C[C@@H]2[C@H](O2)/C=C\C=C\C(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1 |
Relative Density. | 1.364 g/cm3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (219.31 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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