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Radicicol

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Catalog No. T16719Cas No. 12772-57-5
Alias Monorden

Radicicol (Monorden) is an antifungal antibiotic and a potent inhibitor of heat shock protein 90 (Hsp90), which leads to the degradation of Hsp90 by the proteasome by binding to its ATP-binding pocket. In addition, Radicicol inhibits the growth and proliferation of several tumor cell lines. It also has anti-malarial activity and acts as an inhibitor of adipose- and obesity-related proteins (FTO). Radicicol inhibits iNOS gene expression by blocking the p38 kinase signaling pathway and NF-kB/Rel

Radicicol

Radicicol

😃Good
Catalog No. T16719Alias MonordenCas No. 12772-57-5
Radicicol (Monorden) is an antifungal antibiotic and a potent inhibitor of heat shock protein 90 (Hsp90), which leads to the degradation of Hsp90 by the proteasome by binding to its ATP-binding pocket. In addition, Radicicol inhibits the growth and proliferation of several tumor cell lines. It also has anti-malarial activity and acts as an inhibitor of adipose- and obesity-related proteins (FTO). Radicicol inhibits iNOS gene expression by blocking the p38 kinase signaling pathway and NF-kB/Rel
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500 μgInquiry35 days
1 mg$178 35 days
5 mgInquiry35 days
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Product Introduction

Bioactivity
Description
Radicicol (Monorden) is an antifungal antibiotic and a potent inhibitor of heat shock protein 90 (Hsp90), which leads to the degradation of Hsp90 by the proteasome by binding to its ATP-binding pocket. In addition, Radicicol inhibits the growth and proliferation of several tumor cell lines. It also has anti-malarial activity and acts as an inhibitor of adipose- and obesity-related proteins (FTO). Radicicol inhibits iNOS gene expression by blocking the p38 kinase signaling pathway and NF-kB/Rel
Targets&IC50
HSP90:1 μM
In vitro
Radicicol inhibits PDK1 activity with an IC50 value of 230 mM and PDK3 with an IC50 value of 400 μM.[1]
In vivo
Methods: Radicicol (20 mg/kg/60 mg/kg, intraperitoneal injection, 2 doses, 1 h apart) was administered to mice to observe its inhibitory effect on (I/R) injury in mice.
Results: Radicicol has a renal protective effect, improves renal ischemia-reperfusion (I/R) injury, and increases renal HSP70 mRNA and protein in mice with renal injury. [4]
AliasMonorden
Chemical Properties
Molecular Weight364.78
FormulaC18H17ClO6
Cas No.12772-57-5
SmilesC[C@@H]1C[C@@H]2[C@H](O2)/C=C\C=C\C(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1
Relative Density.1.364 g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (219.31 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7414 mL13.7069 mL27.4138 mL137.0689 mL
5 mM0.5483 mL2.7414 mL5.4828 mL27.4138 mL
10 mM0.2741 mL1.3707 mL2.7414 mL13.7069 mL
20 mM0.1371 mL0.6853 mL1.3707 mL6.8534 mL
50 mM0.0548 mL0.2741 mL0.5483 mL2.7414 mL
100 mM0.0274 mL0.1371 mL0.2741 mL1.3707 mL

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