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Biapenem

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Purity:97.83%

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COA HNMR HPLC

Biapenem

Catalog No. T6411Cas No. 120410-24-4

Biapenem (CLI 86815) is a 1-beta-methylcarbapenem antibiotic with a wide range of antibacterial activity. Biapenem has similar antibacterial activity to that of imipenem, but is more stable against human renal dehydropeptidase-I and with less neurotoxicity.

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Pack Size	Price	Availability
5 mg	$32	In Stock
10 mg	$52	In Stock
25 mg	$98	In Stock
50 mg	$163	In Stock
100 mg	$218	In Stock

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Product Introduction

Bioactivity

Description	Biapenem (CLI 86815) is a 1-beta-methylcarbapenem antibiotic with a wide range of antibacterial activity. Biapenem has similar antibacterial activity to that of imipenem, but is more stable against human renal dehydropeptidase-I and with less neurotoxicity.
In vitro	Biapenem has activity comparable to those of Imipenem and Meropenem against all groups of anaerobes with MICs for 90% of the strains tested of 0.06 to 2 mg/mL. Biapenem is more active than ampicillin-sulbactam, ticarcillin-clavulanate, piperacillin, cefoxitin, cefotaxime, and ceftriaxone. Biapenem is also active against all of the B. capillosus, Prevotella, Clostridium, and Eubacterium strains and anaerobic cocci tested. [1] Biapenem shows broad antibacterial activity against both Gram-positive and Gram-negative clinical isolates. [2] Biapenem is found to be approximately as active as imipenem, inhibiting 90% of isolates of most species at concentrations within one dilution of the MIC of imipenem for 90% of the isolates. [3]
In vivo	Biapenem results in significantly fewer viable bacteria than in the lungs of control mice. Biapenem prevents the progression of lung inflammation, including alveolar neutrophil infiltration and hemorrhage. Biapenem significantly prolongs survival and reduces the number of viable bacteria in a murine model of VAP caused by P. aeruginosa. [4]
Alias	CLI 86815, Biapenern, Omegacin, L 627, LJC 10627

Chemical Properties

Molecular Weight	350.39
Formula	C15H18N4O4S
Cas No.	120410-24-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Insoluble

H2O: 10 mM

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
10 mM	0.2854 mL	1.4270 mL	2.8540 mL	14.2698 mL
20 mM	0.1427 mL	0.7135 mL	1.4270 mL	7.1349 mL
50 mM	0.0571 mL	0.2854 mL	0.5708 mL	2.8540 mL
100 mM	0.0285 mL	0.1427 mL	0.2854 mL	1.4270 mL

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