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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $54 | In Stock | |
10 mg | $81 | In Stock | |
25 mg | $145 | In Stock | |
100 mg | $396 | In Stock | |
1 mL x 10 mM (in DMSO) | $74 | In Stock |
Description | Cefoselis Sulfate is a widely used beta-lactam antibiotic. |
In vitro | Cefoselis inhibits GABA-induced currents in a concentration-dependent manner with IC50 of 185 mM. [1] Cefoselis possesses a superior antistaphylococcal activity on MSSA isolates to both other compounds being however equal active to Cefepime and Cefpirome on multiresistant enterobacteriaceae. [2] Cefoselis is dose-dependently appeared in brain extracellular fluid in proportion to its blood level. [3] Cefoselis, a new parenteral cephalosporin, is active against clinical isolates of both gram-positive and gram-negative aerobic bacteria. [4] |
In vivo | Cefoselis elicits a massive elevation of extracellular glutamate concentration in normal rats. [3] Cefoselis (50 mg/animal)-induced convulsions are prevented by pretreatment with 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), diazepam and phenobarbital (ED(50) values (mg/kg) of 0.78, 1.59 and 33.0, respectively), but not by carbamazepine or phenytoin. [5] |
Alias | FK 037 Sulfate, FK-037 |
Molecular Weight | 620.64 |
Formula | C19H22N8O6S2·H2SO4 |
Cas No. | 122841-12-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 27.5 mg/mL (44.31 mM) ![]() | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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