cephalosporin

Cephalosporin P1 is a biochemical.

Cephalosporin C zinc salt was a potent inhibitor of SAMHD1 (IC50 : 1.1 ± 0.1 µM), and this inhibition was largely attributable to the presence of zinc.

Trans-substituted cephalosporin is an efficient inhibitor of NDM-1, demonstrating an IC50 value of 0.13 μM.

Cefuzonam is a novel cephalosporin with anti-inflammatory and antibacterial activity that can be used in studies of respiratory tract infections, tonsillitis, and hepatobiliary infections.

Cefonicid binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Cefonicid sodium (Monocid sodium) is the sodium salt form of cefonicid, a semisynthetic second-generation cephalosporin with antibacterial activity. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

Ceftobiprole (Ro 63-9141) is a broad-spectrum cephalosporin with activity against Methicillin-resistant staphylococcus aureus (MRSA; MIC90: 2 μg/mL).

Cefaclor monohydrate (Cefaclorum) is a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity.

Cefodizime Sodium is a third generation cephalosporin antibiotic, has broad-spectrum activity

Cefditoren pivoxil (ME 1207) is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity.

Cefalonium Dihydrate(5575-21-3 free base) is a first-generation cephalosporin antibiotic.

Ceftriaxone Sodium is a broad-spectrum β-lactam tertiary cephalosporin antibiotic with anti-inflammatory, antitumor, antibacterial, and antioxidant activities.Ceftriaxone Sodium is a covalent GSK3β and Aurora B inhibitor used in the study of sepsis and infective endocarditis.

Cefuracetime (SKF81367) (SKF81367) is a cephalosporin antibiotic.

Cefetamet sodium (Ro 15-8074/001) is an orally available cephalosporin antibiotic with antimicrobial activity and is used to study cirrhosis of the liver and lung infections.

Ceftiofur sodium (Naxcel), an antibiotic of the cephalosporin type (third generation), is used as veterinary medicine.

Cephalexin (Cephacillin) is a cephalosporin antibiotic.

Cefroxadine is an orally active cephalosporin antibiotic with a broad spectrum and a bactericidal action. It showed excellent results in the treatment of acute uncomplicated cystitis (AUC).

Ro-23-9424 is a dual-action cephalosporin with a fleroxacin esterified at the 3' position and aminothiazolylmethoxyimino-type side chain at the 7 position. Ro-23-9424 has broad and potent antibacterial activity in vitro and in vivo.

Ceftaroline fosamil hydrate acetate is a powerful cephalosporin antibiotic that exhibits broad-spectrum efficacy against both Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Streptococcus pneumoniae, and common Gram-negative bacteria. It possesses anti-infective properties suitable for studying complicated skin and skin structure infections (cSSSIs) and community-acquired bacterial pneumonia (CABP) [1] [2] [3].

Desacetyl cefapirin is an active metabolite of the cephalosporin antibiotic cefapirin .1 Desacetyl cefapirin is active against E. coli, K. pneumoniae, P. mirabilis, and S. aureus with MIC values of 120, 24, 34, and 0.42 μg/ml, respectively.References1. Jones, R.N., and Packer, R.R. Cefotaxime, cephalothin, and cephapirin: Antimicrobial activity and synergy studies of cephalosporins with significant in vivo desacetyl metabolite concentrations. Diagn. Microbiol. Infect. Dis. 2(1), 65-68 (1984). Desacetyl cefapirin is an active metabolite of the cephalosporin antibiotic cefapirin .1 Desacetyl cefapirin is active against E. coli, K. pneumoniae, P. mirabilis, and S. aureus with MIC values of 120, 24, 34, and 0.42 μg/ml, respectively. References1. Jones, R.N., and Packer, R.R. Cefotaxime, cephalothin, and cephapirin: Antimicrobial activity and synergy studies of cephalosporins with significant in vivo desacetyl metabolite concentrations. Diagn. Microbiol. Infect. Dis. 2(1), 65-68 (1984).

Cefovecin Sodium(Convenia) is an antibiotic of the cephalosporin class, licensed for the treatment of skin infections in cats and dogs.

Cefpodoxime sodium is a third generation cephalosporin antibiotic agent. It targets gram-positive and gram-negative bacteria, especially those responsible for otitis media and pharyngitis.

Ceftaroline fosamil (TAK-599) inner salt, a cephalosporin derivative, is an N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) T-91825. Ceftaroline fosamil inner salt can be used for the research of MRSA infection.

Cefluprenam is a a cephalosporin type antibacterial agent.

Ceftibuten is a third-generation cephalosporin antibiotic.

Ro 09-1428, a parenteral cephalosporin, has high antipseudomonal activity.

MDK71803 is an important intermediate or precursor for the synthesis of Cefiderocol, a potent siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain.

BO-1236 is an antipseudomonal cephalosporin.

Cefquinome Sulfate is a semisynthetic, broad-spectrum, fourth-generation aminothiazolyl cephalosporin with antibacterial activity.

MDK08445 is an important intermediate or precursor for the synthesis of Cefiderocol, a potent siderophore cephalosporin antibiotic.

Cefaloridine is a first-generation semisynthetic derivative of cephalosporin C. It is unique among cephalosporins in that it exists as a zwitterion. Cephaloridine was very effective to cure pneumococcal pneumonia. It has a high clinical and bacteriologica

Cefamandole is a semisynthetic wide-spectrum cephalosporin with prolonged action. It is used also as the nafate.

Acv tripeptide is a crucial precursor in penicillin and cephalosporin biosyntheses.

Cefetamet, a cephalosporin antibiotic, shows potential for researching upper and lower community-acquired respiratory tract infections [1].

Cefoperazone dihydrate, a semi-synthetic cephalosporin, exhibits a wide range of antibacterial properties.

Cefozopran is a fourth-generation cephalosporin.

Cefmetazole is a second-generation semi-synthetic β-lactam cephalosporin antibiotic with antimicrobial activity.

Cefotetan Sodium, a second-generation cephalosporin, cephamycin antibiotic, is active against a wide range of both aerobic and anaerobic gram-negative and gram-positive bacteria. Cefotetan disrupts the cell wall synthesis by binding to penicillin-binding

Cefalexin hydrochloride is a cephalosporin antibiotic.

Pyrithione sodium is isolated from cephalosporin molecule; some metal complexes of this have fumarate reductase inhibitory activity and may be useful against trypanosomes.

GT-1 (LCB10-0200) is a siderophore-linked cephalosporin compound that effectively combats clinical isolates of various bacterial species, including P. aeruginosa, Klebsiella oxytoca, Proteus spp., Serratia marcescens, and Enterobacter aerogenes.

Cefpirome is a broad-spectrum, fourth-generation cephalosporin. It binds to and inactivates penicillin-binding proteins located on the inner membrane of the bacterial cell wall.

Cefmenoxime is a cephalosporin antibiotic administered intravenously or intramuscularly. It is an effective inhibitor of Enterobacteriaceae and is resistant to beta-lactamase-initiated hydrolysis. It is active against most common gram-positive and gram-ne

T-91825 (PPI-0903M) is a potent N-phosphono-type cephalosporin compound, which serves as the active variant of TAK-599. It exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria [1][2].

Cefonicid monosodium is the salt form of Cefonicid (free base), a second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.

Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.

Cefozopran hydrochloride (SCE-2787 hydrochloride) is a fourth-generation cephalosporin. is a cell wall biosynthesis inhibitor with a broad spectrum of activity against Gram-positive and Gram-negative bacteria.

Ro 41-1879 is a catechol cephalosporin with antimicrobial activity.

A1-226 is a cephalosporin of the class of β-lactam antibiotics, it is originally derived from the fungus Acremonium.

Cefazedone (Refosporen) is a semisynthetic first-generation cephalosporin with activity against Gram-positive and Gram-negative bacteria[1].

ETX0282 is an orally available, broad spectrum inhibitor of class A and C β-lactamases. Entasis is developing ETX0282 in combination with cefpodoxime proxetil, an orally available cephalosporin approved for treatment of a variety of bacterial infections.