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T-91825

Name: T-91825
Brand: TargetMol
SKU: T37966
Price: 29 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T37966Cas No. 189345-04-8

T-91825 (PPI-0903M) is a potent N-phosphono-type cephalosporin compound, which serves as the active variant of TAK-599. It exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria [1][2].

T-91825

Catalog No. T37966Cas No. 189345-04-8

Pack Size	Price	Availability	Quantity
5 mg	Inquiry	Backorder
10 mg	Inquiry	Backorder

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	T-91825 (PPI-0903M) is a potent N-phosphono-type cephalosporin compound, which serves as the active variant of TAK-599. It exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria [1][2].
In vitro	PPI-0903M is very active against S. aureus (MIC50=0.25 μg/mL), including methicillin-resistant (MRSA) strains (MIC50=1 μg/mL)[1].PPI-0903M is active against hetero-vancomycin-intermediate S. aureus (100 strains), with MIC50s ranging from 0.25 to 4 μg/mL[1].
In vivo	AK-599, administered subcutaneously at a dosage of 20 mg/kg three times daily for a duration of 2 days, significantly reduces bacterial cell counts in the lungs by more than 99.9% in a mouse model of pneumonia induced by MRSA[2].

Chemical Properties

Molecular Weight	604.69
Formula	C₂₂H₂₀N₈O₅S₄
Cas No.	189345-04-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (165.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6537 mL	8.2687 mL	16.5374 mL	82.6870 mL
5 mM	0.3307 mL	1.6537 mL	3.3075 mL	16.5374 mL
10 mM	0.1654 mL	0.8269 mL	1.6537 mL	8.2687 mL
20 mM	0.0827 mL	0.4134 mL	0.8269 mL	4.1343 mL
50 mM	0.0331 mL	0.1654 mL	0.3307 mL	1.6537 mL
100 mM	0.0165 mL	0.0827 mL	0.1654 mL	0.8269 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

T-91825T91825T 91825