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Concanamycin A
Catalog No. T14995Cas No. 80890-47-7
Alias X 4357B, Folimycin, Concanamycin, Antibiotic X 4357B
Concanamycin A (Folimycin), a polycyclic lactone antibiotic, is a selective inhibitor of vacuolar H+-ATPase (V-ATPase) and lysosomal acidification, and can be used to study inflammation.Concanamycin A enhances the immune clearance of infected progenitor cells by cytotoxic T lymphocytes, and inhibits Nef et al. from different branches of HIV and simian immunodeficiency virus. Concanamycin A enhances immune clearance of cytotoxic T lymphocytes from infected progenitor cells, inhibits the Nef allele from different branches of HIV and simian immunodeficiency virus, and can be used to study HIV infection.
Concanamycin A
Catalog No. T14995Alias X 4357B, Folimycin, Concanamycin, Antibiotic X 4357BCas No. 80890-47-7
Concanamycin A (Folimycin), a polycyclic lactone antibiotic, is a selective inhibitor of vacuolar H+-ATPase (V-ATPase) and lysosomal acidification, and can be used to study inflammation.Concanamycin A enhances the immune clearance of infected progenitor cells by cytotoxic T lymphocytes, and inhibits Nef et al. from different branches of HIV and simian immunodeficiency virus. Concanamycin A enhances immune clearance of cytotoxic T lymphocytes from infected progenitor cells, inhibits the Nef allele from different branches of HIV and simian immunodeficiency virus, and can be used to study HIV infection.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μg | $273 | 35 days |
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Concentration:1.0 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | Concanamycin A (Folimycin), a polycyclic lactone antibiotic, is a selective inhibitor of vacuolar H+-ATPase (V-ATPase) and lysosomal acidification, and can be used to study inflammation.Concanamycin A enhances the immune clearance of infected progenitor cells by cytotoxic T lymphocytes, and inhibits Nef et al. from different branches of HIV and simian immunodeficiency virus. Concanamycin A enhances immune clearance of cytotoxic T lymphocytes from infected progenitor cells, inhibits the Nef allele from different branches of HIV and simian immunodeficiency virus, and can be used to study HIV infection. |
| In vitro | In CD8+ cytotoxic T lymphocytes (CTLs), Concanamycin A (100 nM; 0, 4, 8, 12, 16, 20 hours) induced rapid cell death instead of apoptosis at 20 hours, without observed nuclear condensation[2]. |
| In vivo | In wild type mice, Concanamycin A (15 mg/kg; intravenous injection at 0, 10, or 24 hours prior to sacrifice) resulted in significant liver injury, as demonstrated by increased serum transaminase levels, inflammatory cell infiltrate, hepatocyte apoptosis, and elevated expression of several cytokines including interleukin 4 (IL4) and interferon gamma (IFNγ) at 10 and 24 hours following administration[5]. |
| Alias | X 4357B, Folimycin, Concanamycin, Antibiotic X 4357B |
| Molecular Weight | 866.09 |
| Formula | C46H75NO14 |
| Cas No. | 80890-47-7 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (9.24 mM), Sonication is recommended. Methanol: 8 mg/mL (9.24 mM), Sonication and heating are recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO/Methanol
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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