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Concanamycin A

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Concanamycin A

Catalog No. T14995Cas No. 80890-47-7

Concanamycin A (Folimycin), a polycyclic lactone antibiotic, is a selective inhibitor of vacuolar H+-ATPase (V-ATPase) and lysosomal acidification, and can be used to study inflammation.Concanamycin A enhances the immune clearance of infected progenitor cells by cytotoxic T lymphocytes, and inhibits Nef et al. from different branches of HIV and simian immunodeficiency virus. Concanamycin A enhances immune clearance of cytotoxic T lymphocytes from infected progenitor cells, inhibits the Nef allele from different branches of HIV and simian immunodeficiency virus, and can be used to study HIV infection.

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Pack Size	Price	Availability	Quantity
100 μg	$273	35 days

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Product Introduction

Bioactivity

Description	Concanamycin A (Folimycin), a polycyclic lactone antibiotic, is a selective inhibitor of vacuolar H+-ATPase (V-ATPase) and lysosomal acidification, and can be used to study inflammation.Concanamycin A enhances the immune clearance of infected progenitor cells by cytotoxic T lymphocytes, and inhibits Nef et al. from different branches of HIV and simian immunodeficiency virus. Concanamycin A enhances immune clearance of cytotoxic T lymphocytes from infected progenitor cells, inhibits the Nef allele from different branches of HIV and simian immunodeficiency virus, and can be used to study HIV infection.
In vitro	In CD8+ cytotoxic T lymphocytes (CTLs), Concanamycin A (100 nM; 0, 4, 8, 12, 16, 20 hours) induced rapid cell death instead of apoptosis at 20 hours, without observed nuclear condensation[2].
In vivo	In wild type mice, Concanamycin A (15 mg/kg; intravenous injection at 0, 10, or 24 hours prior to sacrifice) resulted in significant liver injury, as demonstrated by increased serum transaminase levels, inflammatory cell infiltrate, hepatocyte apoptosis, and elevated expression of several cytokines including interleukin 4 (IL4) and interferon gamma (IFNγ) at 10 and 24 hours following administration[5].
Alias	Folimycin, Concanamycin, X 4357B, Antibiotic X 4357B

Chemical Properties

Molecular Weight	866.09
Formula	C46H75NO14
Cas No.	80890-47-7

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 8 mg/mL (9.24 mM), Sonication is recommended.

Methanol: 8 mg/mL (9.24 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.1155 mL	0.5773 mL	1.1546 mL	5.7731 mL
20 mM	0.0577 mL	0.2887 mL	0.5773 mL	2.8865 mL
50 mM	0.0231 mL	0.1155 mL	0.2309 mL	1.1546 mL
100 mM	0.0115 mL	0.0577 mL	0.1155 mL	0.5773 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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