Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $157 | In Stock | |
5 mg | $392 | In Stock | |
10 mg | $583 | In Stock | |
25 mg | $933 | In Stock | |
50 mg | $1,270 | In Stock | |
100 mg | $1,690 | In Stock |
Description | Magainin II is a member of the antimicrobial peptides family |
In vitro | Magainin 2 exhibits bactericidal activity by permeabilizing cell membranes and inducing early apoptosis-like morphological changes in Escherichia coli. It enhances the expression of a bacterial protein with caspase substrate affinity and modulates RecA expression, akin to caspase-like proteins. Notably, it disrupts membranes without significant harm to mammalian cells, targeting primarily the lipid matrix. In Paramecium caudatum, a protozoan, magainin 2 at 10 μg/mL induces osmotic swelling and cell burst by interfering with membrane functions crucial for osmotic regulation. Its mechanism differs in bacterial and mammalian cells; it forms approximately 2.8 nm pores in B. megaterium membranes and crosses into the cytosol, whereas in CHO-K1 cells, it causes significant membrane disturbance, allowing entry of molecules larger than 23 nm, and results in membrane budding and lipid redistribution, notably affecting mitochondria and nuclei. |
Molecular Weight | 2466.9 |
Formula | C114H180N30O29S |
Cas No. | 108433-95-0 |
Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||
Solubility Information | DMSO: 5 mM | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.