magainin 2

Magainin II is a member of the antimicrobial peptides family

Magainin 2, a cationic peptide derived from the African clawed frog (X. laevis) skin, exhibits host defense and antimicrobial properties. This compound effectively inhibits a range of pathogens, including E. coli, K. pneumoniae, S. epidermidis, S. aureus bacteria, and C. albicans fungus, with minimum inhibitory concentrations (MICs) of 5, 10, 10, 50, and 80 µg/ml, respectively. Additionally, at a concentration of 20 µM, Magainin 2 significantly reduces the germination and tube elongation in kiwi fruit pollen. It also curtails viral replication in Vero cells infected by herpes simplex virus 1 (HSV-1) or HSV-2, with half-maximal effective concentrations (EC50s) of 22.16 and 19.8 µM, respectively, while demonstrating low toxicity to these cells, shown by a 50% cytotoxic concentration (CC50) greater than 100 µM.

Magainin 1 TFA (Magainin I TFA), an antimicrobial and amphipathic peptide derived from Xenopus laevis skin, demonstrates antibiotic efficacy against a broad range of Gram-negative and Gram-positive bacteria [1] [2] [3].

Pexiganan (MSI 78 free base), a synthetic analog of magainin 2, is a potent, broad-spectrum antimicrobial peptide with oral activity. It is utilized in researching infections, including diabetic foot ulcer infections [1].