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Pentachloropseudilin
Pentachloropseudilin (PClP) is a reversible variant 1 myosin inhibitor with antimicrobial activity that inhibits Myo1s and class 5 myosins.Pentachloropseudilin inhibits growth factor-beta (TGF-β), which blocks host cell invasion by Trypanosoma cruzi.
Catalog No. T24612Cas No. 69640-38-6
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Purity:98.14%
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Pentachloropseudilin
Catalog No. T24612Alias PClP, Antibiotic A 15104 YCas No. 69640-38-6
Pentachloropseudilin (PClP) is a reversible variant 1 myosin inhibitor with antimicrobial activity that inhibits Myo1s and class 5 myosins.Pentachloropseudilin inhibits growth factor-beta (TGF-β), which blocks host cell invasion by Trypanosoma cruzi.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | Pentachloropseudilin (PClP) is a reversible variant 1 myosin inhibitor with antimicrobial activity that inhibits Myo1s and class 5 myosins.Pentachloropseudilin inhibits growth factor-beta (TGF-β), which blocks host cell invasion by Trypanosoma cruzi. |
| In vitro | Pentachloropseudoprotein (PCLP) inhibits TGF-β-stimulated Smad2/3 phosphorylation and activation of the plasminogen activator inhibitor-1 (PAI-1) promoter, with an IC50 value of 0.1 μM in target cells (A549, HepG2, and Mv1Lu cells) [2]. Pentachloropseudoprotein reduced TGF-β-stimulated expression of waveform protein, N-adhesin, and fibronectin, thereby blocking TGF-β-induced epithelial-to-mesenchymal transition (EMT) in these cells. Pentachloropseudoprotein (0.05 to 1 μΜ; 0-6 hours) pretreatment inhibited the TGF-β-mediated increase in p-Smad2/3 expression (50 or 100 pM), reducing it by 47% (Mv1Lu) and 79% (A549), respectively [2]. Sucrose density gradient analysis and immunofluorescence staining showed that pentachloro pseudilin (0.2 μM) inhibited TGF-β-stimulated cellular responses by accelerating caveolae-mediated internalization, inhibiting cell surface type II TGF-β receptor expression, and then degrading the receptor primarily through lysosome-dependent degradation [2]. |
| Alias | PClP, Antibiotic A 15104 Y |
| Molecular Weight | 331.41 |
| Formula | C10H4Cl5NO |
| Cas No. | 69640-38-6 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (241.39 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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