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Doramectin

🥰Excellent
Catalog No. T0969Cas No. 117704-25-3
Alias Dectomax, Cyclohexylavermectin B1

Doramectin (Dectomax) is an antiparasitic agent.

Doramectin

Doramectin

🥰Excellent
Purity: 98.4%
Catalog No. T0969Alias Dectomax, Cyclohexylavermectin B1Cas No. 117704-25-3
Doramectin (Dectomax) is an antiparasitic agent.
Pack SizePriceAvailabilityQuantity
50 mg$38In Stock
100 mg$53In Stock
500 mg$91In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Purity:98.4%
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Product Introduction

Bioactivity
Description
Doramectin (Dectomax) is an antiparasitic agent.
Kinase Assay
To determine which caspases are involved in apoptosis induced by taxol, caspase-3 inhibitor (DEVD-CHO), caspase-6 inhibitor (Z-VEID-FMK), caspase-8 inhibitor (Z-IETD-FMK or IETD-CHO), caspase-9 inhibitors (Z-LEHD-FMK or LEHD-CHO), and caspase-10 inhibitor (Z-AEVD-FMK) are used. These caspase inhibitors are dissolved in dimethyl sulfoxide (Me2SO); the final concentration of Me2SO is 0.1%. Cells (5×105) are preincubated in the presence or absence of 100 μM?each of these inhibitors for 3 h at 37°C then treated with or without 0.1, 0.5, and 1 μM?Paclitaxel for 48 h and processed for annexin V binding assay.
AliasDectomax, Cyclohexylavermectin B1
Chemical Properties
Molecular Weight899.11
FormulaC50H74O14
Cas No.117704-25-3
Smiles[H][C@@]12OC\C3=C/C=C/[C@H](C)[C@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)\C(C)=C\C[C@]4([H])C[C@@]([H])(C[C@@]5(O[C@H](C6CCCCC6)[C@@H](C)C=C5)O4)OC(=O)[C@]([H])(C=C(C)[C@H]1O)[C@@]23O
Relative Density.1 114 kg/m3. Temperature:20 °C.
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (33.37 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.1122 mL5.5611 mL11.1221 mL55.6105 mL
5 mM0.2224 mL1.1122 mL2.2244 mL11.1221 mL
10 mM0.1112 mL0.5561 mL1.1122 mL5.5611 mL
20 mM0.0556 mL0.2781 mL0.5561 mL2.7805 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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