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Gramicidin A
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Catalog No. T36439Cas No. 11029-61-1
Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces the degradation of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and reduces the growth of a mouse xenograft model of human renal cell carcinoma. Gramicidin A has antibacterial, antimalarial and hemolytic activities.
Gramicidin A
😃Good
Catalog No. T36439Cas No. 11029-61-1
Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces the degradation of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and reduces the growth of a mouse xenograft model of human renal cell carcinoma. Gramicidin A has antibacterial, antimalarial and hemolytic activities.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $78 | 35 days | |
| 5 mg | $250 | 35 days | |
| 10 mg | $460 | 35 days | |
| 25 mg | $953 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Gramicidin A is a peptide antibiotic isolated from B. brevis.Gramicidin A is a highly hydrophobic channel-forming ion carrier that forms monovalent cation-permeable channels in artificial membranes.Gramicidin A induces the degradation of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and reduces the growth of a mouse xenograft model of human renal cell carcinoma. Gramicidin A has antibacterial, antimalarial and hemolytic activities. |
| Targets&IC50 | A498:0.420 μM, 786-O:0.430 μM, ACHN:0.783, Caki-1 cells:0.228 μM, SN12C:0.104 μM |
| In vitro | Gramicidin A (0.1 nM-10 μM; 72 h) reduces the viability of RCC cell lines and affects cell viability comparable to Monensin.[2] Gramicidin A (1 and 10 μM, 48 or 72 h) induces nonapoptotic cell death in RCC cells.[2] Gramicidin A (0-10 μM, 24 h) depletes cellular energy and induces metabolic dysfunction in RCC cells.[2] Gramicidin A (0-1 μM, 24-72 h) reduces HIF-1α and HIF-2α protein expression and reduces HIF transcriptional activity and target gene expression (24 h).[3] |
| In vivo | Gramicidin A (0.11 mg/kg; intratumoral injection; 2 weeks; 14 days) inhibits the growth of RCC tumor xenografts with an average tumor mass reduction of approximately 40% without significant toxicity.[2] Gramicidin A (0.22 mg/kg; intratumoral injection; 3 weeks; 26 days) inhibits the growth and angiogenesis of VHL-expressing RCC tumor xenografts.[3] |
| Molecular Weight | 1882.29 |
| Formula | C99H140N20O17 |
| Cas No. | 11029-61-1 |
| Smiles | CC(C)CC(NC(=O)C(C)NC(=O)CNC(=O)C(NC=O)C(C)C)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(C(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCO |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: Soluble H2O: Slightly soluble Ethanol: Soluble |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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