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G907

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Purity:98.14%

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COA HNMR LCMS

G907

Catalog No. T11348Cas No. 2244035-16-1

G907 is a selective and potent antagonist of the small molecule ATP-binding cassette (ABC) transporter protein MsbA, with bactericidal activity, which traps MsbA in the inner lipopolysaccharide. G907 inhibits E. coli MsbA with an IC50 value of 18 nM.

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Pack Size	Price	Availability	Quantity
1 mg	$166	In Stock

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Product Introduction

Bioactivity

Description	G907 is a selective and potent antagonist of the small molecule ATP-binding cassette (ABC) transporter protein MsbA, with bactericidal activity, which traps MsbA in the inner lipopolysaccharide. G907 inhibits E. coli MsbA with an IC50 value of 18 nM.
In vitro	G907 inhibits the activity of purified Escherichia coli MsbA with an IC50 value of 18 nM over a concentration range of 0.1 nM to 100 μM[1]. G907 exhibits allosteric inhibitory activity against MsbA[2]. At 100 nM, G907 completely inhibits the transport activity of biotin-PE in liposomes containing MsbA-WT protein[1].

Chemical Properties

Molecular Weight	433.93
Formula	C26H24ClNO3
Cas No.	2244035-16-1

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (138.27 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3045 mL	11.5226 mL	23.0452 mL	115.2260 mL
5 mM	0.4609 mL	2.3045 mL	4.6090 mL	23.0452 mL
10 mM	0.2305 mL	1.1523 mL	2.3045 mL	11.5226 mL
20 mM	0.1152 mL	0.5761 mL	1.1523 mL	5.7613 mL
50 mM	0.0461 mL	0.2305 mL	0.4609 mL	2.3045 mL
100 mM	0.0230 mL	0.1152 mL	0.2305 mL	1.1523 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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