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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $40 | In Stock | |
25 mg | $54 | In Stock | |
50 mg | $74 | In Stock | |
100 mg | $126 | In Stock | |
200 mg | $186 | In Stock | |
500 mg | $297 | In Stock | |
1 g | $459 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Fidaxomicin (Tiacumicin B) is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults. Fidaxomicin has minimal systemic absorption and has not been linked to serum enzyme elevations during therapy or to instances of clinically apparent, acute liver injury. |
In vitro | Fidaxomicin acts as a RNA polymerase inhibitor by binding to the DNA template–RNA polymerase (RNAP) complex prior to the formation of the open RNAP-DNA complex in which transcription is initiated. Therefore it will inhibit protein synthesis. As a result, apoptosis is triggered in susceptible organisms such as C. difficile. [1] |
In vivo | The minimum inhibitory concentration for 90% of organisms for fidaxomicin against C. difficile is 0.9978 to 2 μg/mL. Fidaxomicin is not systemically absorbed as shown by a plasma concentrations below the lower limit of quantification after single-dose or multiple-dose. In contrast, fecal concentrations of fidaxomicin are much higher and are concentration-dependent. Cmax = 2 hours; Tmax = 5.2 ng/mL; AUC = 14 ng?hr/mL. Fidaxomicin is hydrolyzed by gastric acid or intestinal microsomes into a less active metabolite (OP-1118). The cytochrome enzyme system are not involved in the metabolism of fidaxomicin. [1] |
Alias | Tiacumicin B, OPT-80, Clostomicin B1, PAR-101 |
Molecular Weight | 1058.04 |
Formula | C52H74Cl2O18 |
Cas No. | 873857-62-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||
Solubility Information | H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 60 mg/mL (56.71 mM) ![]() | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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