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Fumagillin

🥰Excellent
Catalog No. T6841Cas No. 23110-15-8
Alias NSC9168, Amebacilin

Fumagillin (Amebacilin) is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.

Fumagillin

Fumagillin

🥰Excellent
Purity: 95.75%
Catalog No. T6841Alias NSC9168, AmebacilinCas No. 23110-15-8
Fumagillin (Amebacilin) is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.
Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
5 mg$107In Stock
10 mg$213In Stock
25 mg$353In Stock
50 mg$515In Stock
100 mg$708In Stock
200 mg$956In Stock
1 mL x 10 mM (in DMSO)$109In Stock
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Purity:95.75%
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Product Introduction

Bioactivity
Description
Fumagillin (Amebacilin) is a selective and potent irreversible inhibitor of Methionine aminopeptidase 2 (MetAP2), used as an antibiotic to treat microsporidiosis.
In vitro
Fumagillin selectively inhibits the growth of a Δmap1 strain but not a wild-type or a Δmap2 S. cerevisiae strain missing MetAP-2. [1] In budding yeast cells, as a potent inhibitor of angiogenesis, Fumagillin not only reverses the growth inhibitory activity of Vpr, but also inhibits Vpr-dependent viral gene expression upon the infection of human macrophages. [3] Though the toxicity of fumagillin has limited its use for human applications, the analogues using structure-activity relationships relating to its angiogenesis properties may be further explored in the treatment of angiogenesis-dependent diseases. [4]
In vivo
In DEN-treated rats, fumagillin (30 mg/kg, i.p.) inhibits both progression of HCC in the liver itself and systemic metastasis. [2]
AliasNSC9168, Amebacilin
Chemical Properties
Molecular Weight458.54
FormulaC26H34O7
Cas No.23110-15-8
Smiles[H][C@@]1([C@H](OC)[C@@H](CC[C@]11CO1)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O)[C@@]1(C)O[C@@H]1CC=C(C)C
Relative Density.1.19g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (109.04 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1808 mL10.9042 mL21.8083 mL109.0417 mL
5 mM0.4362 mL2.1808 mL4.3617 mL21.8083 mL
10 mM0.2181 mL1.0904 mL2.1808 mL10.9042 mL
20 mM0.1090 mL0.5452 mL1.0904 mL5.4521 mL
50 mM0.0436 mL0.2181 mL0.4362 mL2.1808 mL
100 mM0.0218 mL0.1090 mL0.2181 mL1.0904 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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