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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $299 | In Stock |
Description | Aclacinomycin A (Aclarubicin) is a novel anthracycline antibiotic isolated from Streptomyces galilei with antitumor activity.Aclacinomycin A is an inhibitor of topoisomerases I and II and inhibits RNA activity.Aclacinomycin A has been used in the study of relapsed leukemia and advanced malignant lymphomas. |
In vitro | In V79 and irs-2 cells, Aclacinomycin A (0, 0.006, 0.12, 1.2, and 2.4 μM; 3 hours) inhibited the catalytic activity of topoisomerase II in a dose-dependent manner. The loss of topoisomerase II catalytic activity in Aclacinomycin A-treated cells was significant in all cases compared to untreated cells[2]. |
In vivo | In DBA/2 and CDF1 (BALB/c×DBA/2) mice weighing 90-110 g with leukemia P-388 model, Aclacinomycin A (0.75 mg/kg, 1.5 mg/kg, 3 mg/kg, 6 mg/kg; intraperitoneal administration daily for 10 days starting 3 hr after transplantation) inhibited tumor growth[4]. |
Alias | Aclarubicin |
Molecular Weight | 811.87 |
Formula | C42H53NO15 |
Cas No. | 57576-44-0 |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (36.95 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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