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Ansamitocin p-3

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Purity:99.73%

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COA HPLC HNMR

Ansamitocin p-3

Catalog No. T22262Cas No. 66584-72-3

Ansamitocin p-3 (Maytansinol isobutyrate) is an inhibitor of microtubule with IC50 of 3.4 μM for tubulin polymerization.

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Pack Size	Price	Availability
1 mg	$51	In Stock
2 mg	$74	In Stock
5 mg	$122	In Stock
10 mg	$178	In Stock
25 mg	$293	In Stock
50 mg	$413	In Stock
100 mg	$547	In Stock
1 mL x 10 mM (in DMSO)	$172	In Stock

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Product Introduction

Bioactivity

Description	Ansamitocin p-3 (Maytansinol isobutyrate) is an inhibitor of microtubule with IC50 of 3.4 μM for tubulin polymerization.
In vitro	Ansamitocin p-3 inhibits the proliferation in a concentration-dependent manner with IC50s of 20, 50, 140, and 150 pM for MCF-7, HeLa, EMT-6/AR1, and MDA-MB-231 cells in culture, respectively. Ansamitocin P3 binds to purified tubulin (Kd = 1.3 µM)[1].
Alias	Maytansinol isobutyrate, Antibiotic C 15003P3, NSC292222

Chemical Properties

Molecular Weight	635.14
Formula	C32H43ClN2O9
Cas No.	66584-72-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 90.0 mg/mL (141.7 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5745 mL	7.8723 mL	15.7446 mL	78.7228 mL
5 mM	0.3149 mL	1.5745 mL	3.1489 mL	15.7446 mL
10 mM	0.1574 mL	0.7872 mL	1.5745 mL	7.8723 mL
20 mM	0.0787 mL	0.3936 mL	0.7872 mL	3.9361 mL
50 mM	0.0315 mL	0.1574 mL	0.3149 mL	1.5745 mL
100 mM	0.0157 mL	0.0787 mL	0.1574 mL	0.7872 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc