Sulfathiazole (2-Sulfanilamidothiazole), an organosulfur compound, has been served as a short-acting sulfa medicine.

Sulfathiazole (20 μg/L) begins degrading between days 31 and 38 in one of two batch reactors with different wastewater matrices, at a faster rate than sulfamethoxazole or sulfamethazine in the nitrification process (S3). [1] Recovery from spiked manure slurry samples is 64% for Sulfathiazole at pH 9. Sulfathiazole, with a pKa of 7.1 and retention times (tR) of 7.8, shows S/N values above 100 at the 1 mg/kg level. [2] Its sorption to inorganic sorbents is pH-dependent, influenced by sorbate speciation and sorbent charge properties, with cations being most significant for clay mineral sorption, followed by neutral species. [3] Sulfathiazole possesses at least five polymorphic forms: I, II, III, IV, and V and exists in the solid state in the imido form. [4] Sulfathiazole (94.9 mg/L) significantly increases reactive oxygen species (ROS) generation and lipid peroxidation under ultraviolet B (UV-B) light exposure, upregulates alpha-esterase, hemoglobin, and vitellogenin mRNA, and significantly affects daphnid survival. [5]