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Sulfanilamide

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Catalog No. T0123Cas No. 63-74-1
Alias UK-124, Sulphanilamide

Sulfanilamide (UK-124) can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.

Sulfanilamide

Sulfanilamide

🥰Excellent
Purity: 99.94%
Catalog No. T0123Alias UK-124, SulphanilamideCas No. 63-74-1
Sulfanilamide (UK-124) can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
Pack SizePriceAvailabilityQuantity
500 mg$30In Stock
1 g$37In Stock
5 g$53In Stock
1 mL x 10 mM (in DMSO)$39In Stock
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Purity:99.94%
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Product Introduction

Bioactivity
Description
Sulfanilamide (UK-124) can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
Targets&IC50
DHPS:320 μM
In vitro
Sulfanilamide was able to inhibit a recombinant yeast strain with a wild-type FOL1 gene with an IC50 of 286.8 μg/mL, but a single mutation in the active region of the fungal dihydropyrimidine synthase from 55Trp to 55Ala or 57Pro to 57Ser resulted in resistance to Sulfanilamide with an IC50 >800 μg/mL. /The sulfonamide group of Sulfanilamide inhibits dihydropyridine synthase purified from E. coli. p-Aminobenzoic acid synthesis is used for essential folic acid in the synthesis of purines, pyrimidines, and other amino acids. The IC50 of Sulfanilamide was 320 μM for dihydropyridine synthase, and the Km was 2.5 uM for PABA. Sulfanilamide was able to inhibit the growth of Plasmodium falciparum-containing pKOS-pfPPPK-DHPS(His) bacterial cells to a certain extent with an IC50 of 380 uM.
In vivo
Sulfanilamide was able to inhibit a recombinant yeast strain with a wild-type FOL1 gene with an IC50 of 286.8 μg/mL, but a single mutation in the active region of the fungal dihydropyrimidine synthase from 55Trp to 55Ala or 57Pro to 57Ser resulted in resistance to Sulfanilamide with an IC50 >800 μg/mL. /The sulfonamide group of Sulfanilamide inhibits dihydropyridine synthase purified from E. coli. p-Aminobenzoic acid synthesis is used for essential folic acid in the synthesis of purines, pyrimidines, and other amino acids. The IC50 of Sulfanilamide was 320 μM for dihydropyridine synthase, and the Km was 2.5 uM for PABA. Sulfanilamide was able to inhibit the growth of Plasmodium falciparum-containing pKOS-pfPPPK-DHPS(His) bacterial cells to a certain extent with an IC50 of 380 uM.
AliasUK-124, Sulphanilamide
Chemical Properties
Molecular Weight172.2
FormulaC6H8N2O2S
Cas No.63-74-1
SmilesNc1ccc(cc1)S(N)(=O)=O
Relative Density.1.08
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (290.36 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 14 mg/mL (81.3 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM5.8072 mL29.0360 mL58.0720 mL290.3600 mL
5 mM1.1614 mL5.8072 mL11.6144 mL58.0720 mL
10 mM0.5807 mL2.9036 mL5.8072 mL29.0360 mL
20 mM0.2904 mL1.4518 mL2.9036 mL14.5180 mL
50 mM0.1161 mL0.5807 mL1.1614 mL5.8072 mL
DMSO
1mg5mg10mg50mg
100 mM0.0581 mL0.2904 mL0.5807 mL2.9036 mL

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