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Sulfanilamide (UK-124) can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $30 | In Stock | |
1 g | $37 | In Stock | |
5 g | $53 | In Stock | |
1 mL x 10 mM (in DMSO) | $39 | In Stock |
Description | Sulfanilamide (UK-124) can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM. |
Targets&IC50 | DHPS:320 μM |
In vitro | Sulfanilamide was able to inhibit a recombinant yeast strain with a wild-type FOL1 gene with an IC50 of 286.8 μg/mL, but a single mutation in the active region of the fungal dihydropyrimidine synthase from 55Trp to 55Ala or 57Pro to 57Ser resulted in resistance to Sulfanilamide with an IC50 >800 μg/mL. /The sulfonamide group of Sulfanilamide inhibits dihydropyridine synthase purified from E. coli. p-Aminobenzoic acid synthesis is used for essential folic acid in the synthesis of purines, pyrimidines, and other amino acids. The IC50 of Sulfanilamide was 320 μM for dihydropyridine synthase, and the Km was 2.5 uM for PABA. Sulfanilamide was able to inhibit the growth of Plasmodium falciparum-containing pKOS-pfPPPK-DHPS(His) bacterial cells to a certain extent with an IC50 of 380 uM. |
In vivo | Sulfanilamide was able to inhibit a recombinant yeast strain with a wild-type FOL1 gene with an IC50 of 286.8 μg/mL, but a single mutation in the active region of the fungal dihydropyrimidine synthase from 55Trp to 55Ala or 57Pro to 57Ser resulted in resistance to Sulfanilamide with an IC50 >800 μg/mL. /The sulfonamide group of Sulfanilamide inhibits dihydropyridine synthase purified from E. coli. p-Aminobenzoic acid synthesis is used for essential folic acid in the synthesis of purines, pyrimidines, and other amino acids. The IC50 of Sulfanilamide was 320 μM for dihydropyridine synthase, and the Km was 2.5 uM for PABA. Sulfanilamide was able to inhibit the growth of Plasmodium falciparum-containing pKOS-pfPPPK-DHPS(His) bacterial cells to a certain extent with an IC50 of 380 uM. |
Alias | UK-124, Sulphanilamide |
Molecular Weight | 172.2 |
Formula | C6H8N2O2S |
Cas No. | 63-74-1 |
Smiles | Nc1ccc(cc1)S(N)(=O)=O |
Relative Density. | 1.08 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (290.36 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 14 mg/mL (81.3 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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