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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $1,895 | Backorder |
Description | Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes. It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell surface. |
Molecular Weight | 852.072 |
Formula | C45H73NO14 |
Cas No. | 81552-33-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | DMSO: Soluble DMF: Soluble Ethanol: Soluble Methanol: Soluble |
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