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Cefoperazone

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Purity:99.41%

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COA HNMR LCMS

Cefoperazone

Catalog No. T6437Cas No. 62893-19-0

Cefoperazone (Medocef) binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. It can inhibit rMrp2-mediated [3H]E217βG uptake (IC50: 199 μM).

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Pack Size	Price	Availability
500 mg	$43	In Stock
1 g	$58	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Product Introduction

Bioactivity

Description	Cefoperazone (Medocef) binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. It can inhibit rMrp2-mediated [3H]E217βG uptake (IC50: 199 μM).
Targets&IC50	[3H]-E217βG uptake (rMrp2-mediated):199 μM
In vivo	After treatment of Cefoperazone (2 g, i.v.), levels in serum range from 202μg/mL to 375 μg/mL depending on the period of drug administration. After intramuscular injection of 2 g of Cefoperazone, the mean peak serum level is 111 μg/mL at 1.5 hours. At 12 hours after dosing, mean serum levels are still 2 to 4 μg/mL. Cefoperazone is 90% bound to serum proteins.
Alias	Cefob, Medocef

Chemical Properties

Molecular Weight	645.67
Formula	C25H27N9O8S2
Cas No.	62893-19-0

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 91 mg/mL (140.9 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5488 mL	7.7439 mL	15.4878 mL	77.4389 mL
5 mM	0.3098 mL	1.5488 mL	3.0976 mL	15.4878 mL
10 mM	0.1549 mL	0.7744 mL	1.5488 mL	7.7439 mL
20 mM	0.0774 mL	0.3872 mL	0.7744 mL	3.8719 mL
50 mM	0.0310 mL	0.1549 mL	0.3098 mL	1.5488 mL
100 mM	0.0155 mL	0.0774 mL	0.1549 mL	0.7744 mL

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