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Eravacycline HCl

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Catalog No. T11227L1
Alias TP-434 HCl, Eravacycline HCL(1207283-85-9 Free bse)

Eravacycline HCl (TP-434 HCl) is potent antibiotic with broad-spectrum antibacterial activity.

Eravacycline HCl

Eravacycline HCl

😃Good
Purity: 95.30%
Catalog No. T11227L1Alias TP-434 HCl, Eravacycline HCL(1207283-85-9 Free bse)
Eravacycline HCl (TP-434 HCl) is potent antibiotic with broad-spectrum antibacterial activity.
Pack SizePriceAvailabilityQuantity
1 mg270 €Backorder
5 mg651 €Backorder
10 mg948 €Backorder
25 mg1.406 €Backorder
50 mg1.890 €Backorder
100 mg2.555 €Backorder
1 mL x 10 mM (in DMSO)899 €Backorder
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Purity:95.30%
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Product Introduction

Bioactivity
Description
Eravacycline HCl (TP-434 HCl) is potent antibiotic with broad-spectrum antibacterial activity.
In vitro
Eravacycline is potent antibiotic against A. baumannii, including isolates that are resistant to sulbactam, meropenem/imipenem, levofloxacin, and tobramycin/amikacin. Eravacycline exhibits greater activity than the comparators of the tetracycline class, levofloxacin, amikacin, tobramycin, and colistin. The eravacycline MIC50/90 values are 0.5/1 mg/L[1].
In vivo
Eravacycline is active in multiple murine models of infection against clinically important Gram-negative and Gram-positive pathogens. Eravacycline is efficacious in mouse septicemia models, demonstrating 50% protective dose values of ≤1 mg/kg of body weight once a day (q.d.) against Staphylococcus aureus, including tetracycline-resistant isolates of methicillin-resistant S. aureus (MRSA), and Streptococcus pyogenes. The PD50s against Escherichia coli isolates are 1.2 to 4.4 mg/kg q.d[2].
AliasTP-434 HCl, Eravacycline HCL(1207283-85-9 Free bse)
Chemical Properties
Molecular Weight595.02
FormulaC27H32ClFN4O8
SmilesO[C@]12[C@](C[C@@]3([H])C(C(C4=C(O)C(NC(CN5CCCC5)=O)=CC(F)=C4C3)=O)=C2O)([H])[C@@H](C(O)=C(C1=O)C(N)=O)N(C)C.Cl
Relative Density.no data available
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (92.43 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6806 mL8.4031 mL16.8062 mL84.0308 mL
5 mM0.3361 mL1.6806 mL3.3612 mL16.8062 mL
10 mM0.1681 mL0.8403 mL1.6806 mL8.4031 mL
20 mM0.0840 mL0.4202 mL0.8403 mL4.2015 mL
50 mM0.0336 mL0.1681 mL0.3361 mL1.6806 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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