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Eravacycline HCl
Catalog No. T11227L1
Alias TP-434 HCl, Eravacycline HCL(1207283-85-9 Free bse)
Eravacycline HCl (TP-434 HCl) is potent antibiotic with broad-spectrum antibacterial activity.
Eravacycline HCl
Catalog No. T11227L1Alias TP-434 HCl, Eravacycline HCL(1207283-85-9 Free bse)
Eravacycline HCl (TP-434 HCl) is potent antibiotic with broad-spectrum antibacterial activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $285 | Backorder | |
| 5 mg | $686 | Backorder | |
| 10 mg | $998 | Backorder | |
| 25 mg | $1,480 | Backorder | |
| 50 mg | $1,990 | Backorder | |
| 100 mg | $2,690 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $947 | Backorder |
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CitedSelect Batch
Purity:95.30%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Eravacycline HCl (TP-434 HCl) is potent antibiotic with broad-spectrum antibacterial activity. |
| In vitro | Eravacycline is potent antibiotic against A. baumannii, including isolates that are resistant to sulbactam, meropenem/imipenem, levofloxacin, and tobramycin/amikacin. Eravacycline exhibits greater activity than the comparators of the tetracycline class, levofloxacin, amikacin, tobramycin, and colistin. The eravacycline MIC50/90 values are 0.5/1 mg/L[1]. |
| In vivo | Eravacycline is active in multiple murine models of infection against clinically important Gram-negative and Gram-positive pathogens. Eravacycline is efficacious in mouse septicemia models, demonstrating 50% protective dose values of ≤1 mg/kg of body weight once a day (q.d.) against Staphylococcus aureus, including tetracycline-resistant isolates of methicillin-resistant S. aureus (MRSA), and Streptococcus pyogenes. The PD50s against Escherichia coli isolates are 1.2 to 4.4 mg/kg q.d[2]. |
| Alias | TP-434 HCl, Eravacycline HCL(1207283-85-9 Free bse) |
| Molecular Weight | 595.02 |
| Formula | C27H32ClFN4O8 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (92.43 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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