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Eravacycline HCl

Catalog No. T11227L1 CAS T11227L1

Synonyms: Eravacycline HCL(1207283-85-9 Free bse), TP-434 HCl

Eravacycline HCl (TP-434 HCl) is potent antibiotic with broad-spectrum antibacterial activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Eravacycline HCl, CAS T11227L1

Pack Size	Availability	Price/USD
1 mg	Inquiry	$ 285.00
5 mg	Inquiry	$ 686.00
10 mg	Inquiry	$ 998.00
25 mg	Inquiry	$ 1,480.00
50 mg	Inquiry	$ 1,990.00
100 mg	Inquiry	$ 2,690.00
1 mL * 10 mM (in DMSO)	In stock	$ 947.00

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Purity: 95.30%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Eravacycline HCl (TP-434 HCl) is potent antibiotic with broad-spectrum antibacterial activity.
In vitro	Eravacycline is potent antibiotic against A. baumannii, including isolates that are resistant to sulbactam, meropenem/imipenem, levofloxacin, and tobramycin/amikacin. Eravacycline exhibits greater activity than the comparators of the tetracycline class, levofloxacin, amikacin, tobramycin, and colistin. The eravacycline MIC50/90 values are 0.5/1 mg/L[1].
In vivo	Eravacycline is active in multiple murine models of infection against clinically important Gram-negative and Gram-positive pathogens. Eravacycline is efficacious in mouse septicemia models, demonstrating 50% protective dose values of ≤1 mg/kg of body weight once a day (q.d.) against Staphylococcus aureus, including tetracycline-resistant isolates of methicillin-resistant S. aureus (MRSA), and Streptococcus pyogenes. The PD50s against Escherichia coli isolates are 1.2 to 4.4 mg/kg q.d[2].

Synonyms	Eravacycline HCL(1207283-85-9 Free bse), TP-434 HCl
Molecular Weight	595.02
Formula	C27H32ClFN4O8
CAS No.	T11227L1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (92.43 mM)

References and Literature

1. Seifert H, et al. In-vitro activity of the novel fluorocycline eravacycline against carbapenem non-susceptible Acinetobacter baumannii. Int J Antimicrob Agents. 2017 Jul 10. 2. Grossman TH, et al. Eravacycline (TP-434) is efficacious in animal models of infection. Antimicrob Agents Chemother. 2015 May;59(5):2567-71.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max Approved Drug Library Anti-Cancer Compound Library

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Eravacycline HCl T11227L1 Microbiology/Virology Antibiotic Eravacycline HCL(1207283-85-9 Free bse) TP-434 HCl inhibitor inhibit

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