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Eravacycline dihydrochloride

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Purity:100%

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COA FNMR HNMR IC LCMS

Eravacycline dihydrochloride

Catalog No. T11227LCas No. 1334714-66-7

Eravacycline dihydrochloride (TP-434-046) is a potent and broad-spectrum antibacterial agent against six E. coli (MICs: 0.125-0.25 mg/L).

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Pack Size	Price	Availability
1 mg	$197	In Stock
5 mg	$690	In Stock
10 mg	$872	In Stock
25 mg	$1,990	In Stock
50 mg	$2,680	In Stock
100 mg	$3,590	In Stock

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Product Introduction

Bioactivity

Description	Eravacycline dihydrochloride (TP-434-046) is a potent and broad-spectrum antibacterial agent against six E. coli (MICs: 0.125-0.25 mg/L).
In vitro	Eravacycline shows inhibitory activity against A. baumannii, including isolates that are resistant to sulbactam, SM 7338, and BAY 41-6551(MIC50/90 = 0.5/1 mg/L)[1]. Eravacycline shows potent broad-spectrum activity against 90% of the isolates for all species panels (MIC90 0.008-2 μg/mL) except those of Pseudomonas aeruginosa and Burkholderia cenocepacia (MIC90 = 32 μg/mL). Eravacycline is active against multidrug-resistant bacteria including β-lactamases and antibiotics, including carbapenem resistance[4].
In vivo	Eravacycline(3.125-50 mg/kg) shows mean fAUC/MIC magnitude associated with net stasis and 1-log kill endpoint of 27.97 and 32.60[2]. In mouse septicemia models, Eravacycline is efficacious against Staphylococcus aureus and demonstrates 50% protective dose values of ≤1 mg/kg. The PD50s are 1.2-4.4 mg/kg against Escherichia coli isolates[5].
Alias	TP-434-046, TP-434 dihydrochloride

Chemical Properties

Molecular Weight	631.48
Formula	C27H33Cl2FN4O8
Cas No.	1334714-66-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 135.0 mg/mL (213.8 mM)

H2O: 45.0 mg/mL (71.3 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.5836 mL	7.9179 mL	15.8358 mL	79.1791 mL
5 mM	0.3167 mL	1.5836 mL	3.1672 mL	15.8358 mL
10 mM	0.1584 mL	0.7918 mL	1.5836 mL	7.9179 mL
20 mM	0.0792 mL	0.3959 mL	0.7918 mL	3.9590 mL
50 mM	0.0317 mL	0.1584 mL	0.3167 mL	1.5836 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0158 mL	0.0792 mL	0.1584 mL	0.7918 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc