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Cyclo-L-Trp-L-Trp

Catalog No. T19717Cas No. 20829-55-4

Cyclo-L-Trp-L-Trp is a broad-spectrum antifungal. It also induces a high degree of acetylation of histones.

Cyclo-L-Trp-L-Trp

Cyclo-L-Trp-L-Trp

Purity: 96.37%
Catalog No. T19717Cas No. 20829-55-4
Cyclo-L-Trp-L-Trp is a broad-spectrum antifungal. It also induces a high degree of acetylation of histones.
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10 mg$30In Stock
25 mg$47In Stock
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Purity:96.37%
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Product Introduction

Bioactivity
Description
Cyclo-L-Trp-L-Trp is a broad-spectrum antifungal. It also induces a high degree of acetylation of histones.
In vitro
Two novel cyclic hexapeptides designated actinosynneptides A (1) and B (2), together with three tryptophan containing diketopiperazines, namely cyclo(L-Trp-L-Trp) (3), cyclo(L-Trp-N-MeL-Trp) (4), and cyclo(N-MeL-Trp-N-MeL-Trp) (5), were isolated from the culture of the genetically engineered strain HGF052::asm18 derived from Actinosynnema pretiosum ATCC31565. Their structures were elucidated on the basis of spectroscopic analyses and single-crystal X-ray diffractions. Compound 1 is the first example of 3-amino-6-hydroxy-2-piperidone-containing cyclic peptides, and 1 and 2 showed moderate cytotoxic activities against HeLa and PC3 cell lines[1].
Chemical Properties
Molecular Weight372.42
FormulaC22H20N4O2
Cas No.20829-55-4
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (80.56 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6851 mL13.4257 mL26.8514 mL134.2570 mL
5 mM0.5370 mL2.6851 mL5.3703 mL26.8514 mL
10 mM0.2685 mL1.3426 mL2.6851 mL13.4257 mL
20 mM0.1343 mL0.6713 mL1.3426 mL6.7129 mL
50 mM0.0537 mL0.2685 mL0.5370 mL2.6851 mL

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