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Ascomycin

Catalog No. T2481Cas No. 104987-12-4
Alias Immunomycin, FR-900520, FK520

Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.

Ascomycin

Ascomycin

Purity: 99.94%
Catalog No. T2481Alias Immunomycin, FR-900520, FK520Cas No. 104987-12-4
Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
Pack SizePriceAvailabilityQuantity
5 mg$36In Stock
10 mg$52In Stock
50 mg$63In Stock
100 mg$81In Stock
500 mg$192Backorder
1 mL x 10 mM (in DMSO)$54In Stock
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Purity:99.94%
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Product Introduction

Bioactivity
Description
Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
Targets&IC50
Calcineurin phosphatase:49 nM
In vitro
Intramuscular injection of 3.2 mg/kg Ascomycin significantly prolonged the survival rate of rats with skin transplants. When administered into the rat hippocampus, Ascomycin at concentrations of 50 or 100 μM exhibited anticonvulsant effects against seizures induced by pentylenetetrazol.
In vivo
Ascomycin inhibits calcineurin by forming an FKBP12-FK520-calcineurin complex, with an IC50 of 49 nM. Additionally, FK520 accelerates neural regeneration and promotes neurite outgrowth. Ascomycin exhibits antimalarial effects by inhibiting the molecular chaperone activity of a bifunctional protein. Moreover, ascomycin suppresses the in vitro immune response of mixed lymphocytes in mice, with an IC50 of 0.55 nM.
AliasImmunomycin, FR-900520, FK520
Chemical Properties
Molecular Weight792.01
FormulaC43H69NO12
Cas No.104987-12-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (56.82 mM)
Ethanol: 39.6 mg/mL (50 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM1.2626 mL6.3131 mL12.6261 mL63.1305 mL
5 mM0.2525 mL1.2626 mL2.5252 mL12.6261 mL
10 mM0.1263 mL0.6313 mL1.2626 mL6.3131 mL
20 mM0.0631 mL0.3157 mL0.6313 mL3.1565 mL
50 mM0.0253 mL0.1263 mL0.2525 mL1.2626 mL

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