Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 197.00 | |
5 mg | In stock | $ 497.00 | |
10 mg | In stock | $ 693.00 | |
25 mg | In stock | $ 1,080.00 | |
50 mg | In stock | $ 1,450.00 | |
100 mg | In stock | $ 1,960.00 | |
500 mg | In stock | $ 3,930.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 445.00 |
Description | Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. |
In vitro | Pyoluteorin is an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, were identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5[1]. Pyoluteorin has significant cytotoxicity towards MCF-7 (IC50=1.84 μM). Pyoluteorin also displays significantly selective cytotoxicity against BT474, HCC1954, MAD-MB-468, MDA-MB-231, and MCF-10A cells with IC50 values of 9.75±0.16, 0.94±0.01, 3.89±0.08, 0.97±0.01, and 57.01±0.76 μM, respectively[2]. Pyoluteorin (0.1-10 μM; for 24 hours) induces change of apoptosis-related protein expressions. Pyoluteorin-induced cell apoptosis in MDA-MB-231 is related to Bcl-2 family proteins and caspase cascade[2]. Pyoluteorin (0.1-10 μM; for 24 h) induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231[2]. |
Molecular Weight | 272.08 |
Formula | C11H7Cl2NO3 |
CAS No. | 25683-07-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (202.15 mM)
You can also refer to dose conversion for different animals. More
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Pyoluteorin 25683-07-2 Microbiology/Virology Antibiotic inhibitor inhibit