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Pyoluteorin

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Catalog No. T21771Cas No. 25683-07-2

Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses related plant diseases. Additionally, Pyoluteorin induces apoptosis in human triple-negative breast cancer (MDA-MB-231) cells in vitro.

Pyoluteorin

Pyoluteorin

🥰Excellent
Purity: 100%
Catalog No. T21771Cas No. 25683-07-2
Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses related plant diseases. Additionally, Pyoluteorin induces apoptosis in human triple-negative breast cancer (MDA-MB-231) cells in vitro.
Pack SizePriceAvailabilityQuantity
1 mg187 €In Stock
5 mg472 €In Stock
10 mg658 €In Stock
25 mg1.026 €In Stock
50 mg1.377 €In Stock
100 mg1.862 €In Stock
500 mg3.733 €In Stock
1 mL x 10 mM (in DMSO)422 €In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses related plant diseases. Additionally, Pyoluteorin induces apoptosis in human triple-negative breast cancer (MDA-MB-231) cells in vitro.
In vitro
Pyoluteorin, an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, was identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5[1]. It exhibits significant cytotoxicity towards MCF-7 cells (IC50=1.84 μM) and selective cytotoxicity against BT474, HCC1954, MAD-MB-468, MDA-MB-231, and MCF-10A cells with IC50 values of 9.75±0.16, 0.94±0.01, 3.89±0.08, 0.97±0.01, and 57.01±0.76 μM, respectively[2]. Treatment with Pyoluteorin (0.1-10 μM; for 24 hours) induces changes in apoptosis-related protein expressions and promotes cell apoptosis in MDA-MB-231 cells via Bcl-2 family proteins and caspase cascade, additionally causing cell cycle arrest in these human triple-negative breast cancer cells[2].
Chemical Properties
Molecular Weight272.08
FormulaC11H7Cl2NO3
Cas No.25683-07-2
SmilesOc1cccc(O)c1C(=O)c1cc(Cl)c(Cl)[nH]1
Relative Density.1.632g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (202.15 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6754 mL18.3769 mL36.7539 mL183.7695 mL
5 mM0.7351 mL3.6754 mL7.3508 mL36.7539 mL
10 mM0.3675 mL1.8377 mL3.6754 mL18.3769 mL
20 mM0.1838 mL0.9188 mL1.8377 mL9.1885 mL
50 mM0.0735 mL0.3675 mL0.7351 mL3.6754 mL
100 mM0.0368 mL0.1838 mL0.3675 mL1.8377 mL

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