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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $39 | In Stock | |
25 mg | $80 | In Stock | |
50 mg | $128 | In Stock | |
100 mg | $197 | In Stock | |
200 mg | $293 | In Stock | |
500 mg | $497 | In Stock | |
1 mL x 10 mM (in DMSO) | $43 | In Stock |
Description | Tulathromycin A (CP 472295) is a macrolide antibiotic. |
Targets&IC50 | Antibacterial:1 microg/ml (MIC90 for Pasteurella multocida) |
In vitro | 145 calves were inoculated by two highly pathogenic strains of M. bovis (with minimum inhibitory concentration values for tulathromycin of 1 and >64 μg/ml). Four days after inoculation, calves with clinical BRD were treated subcutaneously with saline or tulathromycin (2.5 mg/kg). Compared with saline, BRD-related withdrawals, peak rectal temperatures, and lung lesion scores were significantly lower for tulathromycin-treated calves (P < .01). Tulathromycin was highly effective in the treatment of BRD due to M. bovis in calves regardless of the minimum inhibitory concentration of the challenge strain (1 or >64 μg/ml). The MIC90 for tulathromycin were 1 μg/ml for Pasteurella multocida (bovine), 2 μg/ml for Mannheimia (Pasteurella) haemolytica, and 2 μg/ml for Pasteurella multocida (porcine) and ranged from 4-16 μg/ml for Actinobacillus pleuropneumoniae and from 0.5-4 μg/ml for Histophilus somni (Haemophilus somnus). |
In vivo | Each study randomly allocated 250 calves to receive tulathromycin at 2.5 mg/kg and 250 calves to receive either florfenicol at 40 mg/kg or tilmicosin at 10 mg/kg on arrival at the feedlot. Calves were housed by treatment group in pens with 50 calves/pen. The treatment groups were physiologic saline (n=160) given SC at 0.02 ml/kg, tulathromycin (n=20) given SC at 2.5 mg/kg, and tilmicosin (n = 320) given SC at 10 mg/kg. |
Alias | CP 472295, Draxxin, Tulathromycin |
Molecular Weight | 806.08 |
Formula | C41H79N3O12 |
Cas No. | 217500-96-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (74.43 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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