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SPR206

Name: SPR206
Brand: TargetMol
SKU: T12991
Rating: 4.5 (1 reviews)

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Catalog No. T12991

SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen.

SPR206

😃Good

Catalog No. T12991

SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen.

Pack Size	Price	Availability	Quantity
100 mg	Inquiry	Backorder
500 mg	Inquiry	Backorder

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen.
Targets&IC50	Pseudomonas aeruginosa Pa14:（MIC）0.125 mg/L , Acinetobacter baumannii (NCTC13301):0.125 mg/L
In vitro	SPR206 exhibits potent antimicrobial effects against Gram-negative bacteria, displaying Minimum Inhibitory Concentration (MIC) values indicating its effectiveness: 8 mg/L for E. coli IHMA558090, 0.125 mg/L for E. coli ATCC 25922 and A. baumannii ATCC 19003, 0.125 mg/L for K. pneumoniae ATCC 13882, 0.25 mg/L for P. aeruginosa ATCC 27853, and 0.06 mg/L for A. baumannii NCTC13424. Additionally, it demonstrates reduced cytotoxicity [1].
In vivo	In lung tissue and in the thigh model,SPR206 (0.125-30 mg/kg; intravenous injection or subcutaneous injection; every 8 hours or every 4 hours; for 16 hours or 24 hours; neutropenic mice) treatment reduces the burden of Pa14 and NCTC13301 [2].

Chemical Properties

Molecular Weight	1144.75
Formula	C₅₂H₈₂ClN₁₅O₁₂
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SPR-206SPR206SPR 206Pseudomonas aeruginosa Pa14Acinetobacter baumannii NCTC13301