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Fluconazole
🥰Excellent
Catalog No. T1388Cas No. 86386-73-4
Alias UK-49858
Fluconazole (UK-49858) is a triazole antifungal agent used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.
Fluconazole
🥰Excellent
Purity: 99.17%
Catalog No. T1388Alias UK-49858Cas No. 86386-73-4
Fluconazole (UK-49858) is a triazole antifungal agent used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $36 | In Stock | |
| 100 mg | $48 | In Stock | |
| 200 mg | $59 | In Stock | |
| 500 mg | $72 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock |
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Purity:99.17%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Fluconazole (UK-49858) is a triazole antifungal agent used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. |
| In vitro | Fluconazole significantly affects the fungicidal activity of 5-fluorocytosine against cryptococcal meningitis in mice. It is highly effective in extending the survival period of rats infected with representative Candida strains. Compared to the activity of each drug used alone, the combination of fluconazole with 5-fluorocytosine and amphotericin B exhibits markedly improved activity against cryptococcal meningitis. |
| In vivo | Under physiological pH conditions, Fluconazole's activity against 35 Candida albicans strains is 16-fold lower than that of Ketoconazole. When used in combination with Amphotericin B, Fluconazole exhibits synergistic effects against C. albicans cells, yet it does not alter the anti-biofilm activity of AmB. Fluconazole, alongside Caspofungin, antagonizes biofilm formation but has no effect on planktonic cells. Significantly, Fluconazole reduces ergosterol levels in C. albicans planktonic cells, leading to membrane perturbation. Its activity is less sensitive to acidic conditions compared to Ketoconazole. Additionally, the combined use of Fluconazole and Itraconazole shows effective activity against various Candida species, including Fluconazole-resistant strains of C. albicans and Candida tropicalis. |
| Alias | UK-49858 |
| Molecular Weight | 306.27 |
| Formula | C13H12F2N6O |
| Cas No. | 86386-73-4 |
| Smiles | OC(CN1C=NC=N1)(CN1C=NC=N1)C1=C(F)C=C(F)C=C1 |
| Relative Density. | 1.49 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 30.6 mg/mL (100 mM) DMSO: 55 mg/mL (179.58 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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