triazole

It has been granted to have property to inhibit protein isoprenyl transferases.

3-Amino-1,2,4-triazole (Trapidil impurity B) is an inhibitor of catalase, capable of inducing the compensatory mechanism for hydrogen peroxide detoxification. This mechanism involves increasing the activities of glutathione peroxidase and glutathione reductase.

Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T66475 and the CAS number is 217448-86-7.

1-Methyl-1,2,4-triazole is a useful organic compound for research related to life sciences. The catalog number is T67137 and the CAS number is 6086-21-1.

4-Phenyl-1H-1,2,3-triazole, an inhibitor of the enzyme IDO1 (IC50: 60 µM), is utilized in cancer research [1].

1H-1,2,4-Triazole-1-carboximidamide hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67127 and the CAS number is 19503-26-5.

1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate is a useful organic compound for research related to life sciences. The catalog number is T67318 and the CAS number is 86386-77-8.

Ethyl 1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T67440 and the CAS number is 361990-21-8.

Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA is a double claevable 3-unit and 4-unit PEG linker for antibody-drug-conjugation (ADC).

FSEN1 is a novel and highly effective non-competitive FSP1 inhibitor with an IC50 value of 313 nM. FSEN1 induces ferroptosis in cancer cells by inhibiting FSP1. FSEN1 can be used to prevent and treat cancer.

1-Aminobenzotriazole (ABT) (ABT) is a non-specific cytochrome P450 (CYP) inhibitor.

Nucleoside Derivatives - Other modified nucleosides; Drugs and Inhibitors; Ribavirin related compound A; metabolite of Ribavirin

Inz-1 is an effective and fungal-selective inhibitor of mitochondrial cytochrome bc1 with IC50s of 8.092 and 45.320 μM for yeast and human. Inz-1 reverses Fluconazole or other triazole antifungals’ resistance in the pathogenic fungus Candida albicans.

Carboxyamidotriazole Orotate (L-651582 Orotate) is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor that in vitro has been shown to possess antileukaemic activities. Carboxyamidotriazole Orotate shows anti-tumor, anti-inflammatory, and antiangiogenic effects.

CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC).. CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a noncleavable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. .

DO34 analog is a triazole DAGL(α) inhibitor.

Farnesylthiotriazole is a persistent PKC activator agent.

Carboxyamidotriazole is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways. It shows anti-inflammatory, anti-tumor, and antiangiogenic effects.

Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.

Isavuconazole (RO-0094815)(BAL-4815; RO-0094815) is the active component of the new azole antifungal agent BAL8557 with MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata.

Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.

Fluconazole (UK-49858) is a triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.

Tris(benzyltriazolylmethyl)amine (TBTA) is a tertiary amine with three 1, 2, 3-triazole groups. It complexes with, and stabilizes, copper(I) to accelerate azide-alkyne cycloadditions, as used in click chemistry.

MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).

MIND4-19 is an inhibitor of SIRT2 with antitumor activity.

Posaconazole-D4, a deuterium-labeled variant of Posaconazole, is a broad-spectrum, second-generation triazole with antifungal activity.

TIS108, a triazole-type strigolactone biosynthetic inhibitor, impedes embryogenesis in Arabidopsis and diminishes the concentration of 2′-epi-5-deoxystrigol (epi-5DS) in rice [1].

N-(2-Azidoethyl)betulonamide is a pentacyclic triterpenoid, a derivative of betulonic acid , and an intermediate in the synthesis of betulonic acid derivatives within vitrocancer cell cytotoxicity.1 1.Suman, P., Patel, A., Solano, L., et al.Synthesis and cytotoxicity of Baylis-Hillman template derived betulinic acid-triazole conjugatesTetrahedron73(29)4214-4226(2017)

Ravuconazole (ER-30346) is a potent triazole antifungal that potently inhibits a wide range of fungi.

Hydroxy Itraconazole D8 is the deuterium-labeled Hydroxy Itraconazole. Hydroxy Itraconazole is an active metabolite of Itraconazole, which is a triazole antifungal agent.

Triticonazole is a triazole pesticide and fungicide. Triticonazole shows endocrine disrupting activities.

Voriconazole N-oxide is a major metabolite of the triazole antifungal voriconazole . It is formed via oxidation of voriconazole by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C19.

Posaconazole-D5, a deuterium-labeled variant of Posaconazole, is a second-generation, broad-spectrum triazole compound with antifungal activity.

ICMT-IN-35 (compound 10n), an ICMT inhibitor with an IC50 value of 0.8 μM, is a FTPA-triazole derivative. It demonstrates cellular uptake by mammalian cells, disrupts K-Ras membrane association, and induces K-Ras mislocalization. Additionally, ICMT-IN-35 exhibits selective cytotoxicity towards ICMT +/+ MEF cells and possesses potent activity against metastatic pancreatic cancer cell lines with an IC 50 of 0.8 μM [1].

3-Azidopropionic Acid Sulfo-NHS Ester is a water-soluble compound containing an azide group and an NHS ester. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the p

α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide. [1] It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with α-GalCer analog 8 at a concentration of 32 ng/ml. α-GalCer analog 8 (32 ng/ml) induces IL-4 secretion to a greater extent than the synthetic α-GalCer KRN 7000 in mouse splenocytes in vitro and in mouse serum following administration of a 1 µg per animal dose, indicating a Th2 response.

Sch 39304 is an oral triazole antifungal.

Anticancer agent 136 (compound 22), a C17-triazole analogue of Geldanamycin (GDM), exhibits an IC50 value of 3.38 μM against human dermal fibroblasts (HDF) and binds to Heat shock protein 90 (Hsp90) with a dissociation constant (Kd) of 3.86 μM, demonstrating its apoptosis-inducing capabilities [1].

Cyproconazole is a triazole fungicide. It is used agriculturally for protection of crops against a wide variety of fungal pathogens.

Isavuconazole D4 is a deuterium labeled Isavuconazole. Isavuconazole is a triazole prodrug with antifungal activity against yeasts, molds, and dimorphic fungi.

Bitertanol (KWG 0599) is a triazole fungicide. Bitertanol inhibits demethylation, disrupts membrane function, and prevents sterol synthesis.

Hexaconazole ((-)-Hexaconazol) is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.

Propargyl-PEG3-amine is a PEG derivative containing a propargyl group and an amino group. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper-catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.

Flutriafol is a pesticide, demethylation inhibitor, and NMDA receptor agonist

Fluconazole (hydrate) is a triazole antifungal agent used for the oral treatment and prevention of both superficial and systemic fungal infections, including but not limited to balanitis, various Candida infections, Cryptococcus infections, dermatomycosis, and fungal infections of the respiratory and urinary tracts. As the hydrate salt form of fluconazole, it exhibits antifungal activity by inhibiting the growth and development of pathogenic fungi, such as Candida species, at minimal inhibitory concentrations often exceeding 100 mg/l. Notably, it disrupts the branching and hyphal formation in C. albicans at concentrations as low as 0.3 mg/l, indicating its potency in comparison to other antifungals like miconazole and ketoconazole which require 100-fold lower concentrations to be effective. Clinical studies have not linked oral fluconazole with a significant increase in the risk of most birth defects, although there may be an associated risk of tetralogy of Fallot. Its efficacy against Cryptococcus gattii in koalas suggests it may be ineffective as a sole therapeutic agent at a dosage of 10 mg/kg orally every 12 h. Toxicity symptoms from overdose can include hallucinations and paranoid behavior.

Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per day) administered during gestation reduces testosterone levels and increases testicular levels of progesterone and 17α-hydroxyprogesterone in male rat fetuses. It has a feminizing effect on male pups and a virializing effect on female pups. When administered to rats gestationally through postnatal day 42, tebuconazole (20 and 60 mg/kg per day) leads to cell death of pyramidal cells in the CA3-4 region of the hippocampus and layer V of the cortex concomitant with impairment in learning......

Neuraminidase-IN-6 (Compound 5c) is a derivative of 1,3,4-triazole-3-acetamide. Neuraminidase-IN-6 is a potent neuraminidase inhibitor with an IC50 value of 0.11 μM. Neuraminidase (NA) is an ideal target for the anti-influenza drugs development [1].

Antifungal agent 31 is an orally active, triazole antifungal agent possessing a pyrrolizinone scaffold that exhibits some antifungal activity against Candida and filamentous fungi.Antifungal agent 31 significantly reduced mortality and renal fungal burden in two mouse models of lethal systemic infection.

VEGFR-2-IN-12 (compound 6g), a 2-oxoquinoxalinyl-1,2,4-triazole, is a potent inhibitor of VEGFR-2 (IC50: 0.037 μM). VEGFR-2-IN-12 has anti-tumour effects.

Brassinazole is a selective inhibitor of triazole-type steroid (BR) biosynthesis.Brassinazole can be used to modulate the oleuropein steroid (BR) signaling pathway, which is used to regulate plant xylem growth and development.