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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $33 | In Stock | |
10 mg | $54 | In Stock | |
25 mg | $94 | In Stock | |
50 mg | $153 | In Stock | |
100 mg | $276 | In Stock | |
200 mg | $412 | In Stock | |
500 mg | $673 | In Stock | |
1 mL x 10 mM (in DMSO) | $50 | In Stock |
Description | Rufinamide (E 2080), a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders. |
In vitro | Rufinamide effectively suppresses maximal electroshock (MES)-induced tonic convulsions in mice (ED50 = 23.9 mg/kg) and rats (ED50 = 6.1 mg/kg). Additionally, Rufinamide inhibits pentylenetetrazol-(ED 50=54.0), bicuculline-(ED 50=50.5), and picrotoxin (ED 50=76.3 mg/kg) provoked clonic seizures in mice. Furthermore, it prevents pentylenetetrazole-induced epileptic seizures in mice at an effective dose of 45.8 mg/kg (ED50). |
In vivo | Rufinamide inhibits sodium-dependent action potentials in neurons, potentially exhibiting membrane stabilizing effects. |
Alias | CGP 33101, E 2080, RUF 331 |
Molecular Weight | 238.19 |
Formula | C10H8F2N4O |
Cas No. | 106308-44-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||
Solubility Information | DMSO: 16.67 mg/mL (69.97 mM) ![]() Ethanol: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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