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Rufinamide

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Catalog No. T2523Cas No. 106308-44-5
Alias RUF 331, E 2080, CGP 33101

Rufinamide (E 2080), a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders.

Rufinamide

Rufinamide

🥰Excellent
Purity: 99.89%
Catalog No. T2523Alias RUF 331, E 2080, CGP 33101Cas No. 106308-44-5
Rufinamide (E 2080), a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders.
Pack SizePriceAvailabilityQuantity
25 mg$56In Stock
50 mg$93In Stock
100 mg$179In Stock
200 mg$268In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Purity:99.89%
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Product Introduction

Bioactivity
Description
Rufinamide (E 2080), a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders.
In vitro
Rufinamide effectively suppresses maximal electroshock (MES)-induced tonic convulsions in mice (ED50 = 23.9 mg/kg) and rats (ED50 = 6.1 mg/kg). Additionally, Rufinamide inhibits pentylenetetrazol-(ED 50=54.0), bicuculline-(ED 50=50.5), and picrotoxin (ED 50=76.3 mg/kg) provoked clonic seizures in mice. Furthermore, it prevents pentylenetetrazole-induced epileptic seizures in mice at an effective dose of 45.8 mg/kg (ED50).
In vivo
Rufinamide inhibits sodium-dependent action potentials in neurons, potentially exhibiting membrane stabilizing effects.
AliasRUF 331, E 2080, CGP 33101
Chemical Properties
Molecular Weight238.19
FormulaC10H8F2N4O
Cas No.106308-44-5
SmilesNC(=O)C1=CN(CC2=C(F)C=CC=C2F)N=N1
Relative Density.1.52 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 16.67 mg/mL (69.97 mM), Sonication is recommended.
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.1983 mL20.9916 mL41.9833 mL209.9165 mL
5 mM0.8397 mL4.1983 mL8.3967 mL41.9833 mL
10 mM0.4198 mL2.0992 mL4.1983 mL20.9916 mL
20 mM0.2099 mL1.0496 mL2.0992 mL10.4958 mL
50 mM0.0840 mL0.4198 mL0.8397 mL4.1983 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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