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Bitertanol (KWG 0599) is a triazole fungicide. Bitertanol inhibits demethylation, disrupts membrane function, and prevents sterol synthesis.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | 47 € | In Stock | |
10 mg | 66 € | In Stock | |
25 mg | 108 € | In Stock | |
50 mg | 158 € | In Stock | |
100 mg | 235 € | In Stock | |
1 mL x 10 mM (in DMSO) | 59 € | In Stock |
Description | Bitertanol (KWG 0599) is a triazole fungicide. Bitertanol inhibits demethylation, disrupts membrane function, and prevents sterol synthesis. |
In vivo | Bitertanol (10, 25, and 100 mg/kg) produced 2-, 4-, and 14-fold increases of 7-ethoxyresorufin O-deethylation activity in liver microsomes, respectively. Bitertanol (25 mg/kg) increased CYP1A1 protein in the liver, kidney, and lung by 10-, 13-, and 17-fold, respectively. Bitertanol produced smaller increases of CYP2B and CYP3A catalytic activity and protein than that of CYP1A1 in liver. Additions of 0.01-100 microM Bitertanol to liver microsomes from rats Bitertanol (25 mg/kg) inhibited microsomal 7-ethoxyresorufin O-demethylation activity (IC50=0.8 microM). Bitertanol (100 mg/kg) increased liver UDP-glucuronosyltransferase and glutathione S-transferase activities by 2-fold. Bitertanol (25 mg/kg) produced a minor increase in metabolic activation of benzo[a]pyrene by liver S-9 fraction in the Ames mutagenicity test while the increase was blocked by addition of 100 microM Bitertanol[2]. |
Alias | Sibutol, KWG-0599, KWG0599, KWG 0599, Biloxazol, Baycor |
Molecular Weight | 337.42 |
Formula | C20H23N3O2 |
Cas No. | 55179-31-2 |
Smiles | C(OC1=CC=C(C=C1)C2=CC=CC=C2)(C(C(C)(C)C)O)N3C=NC=N3 |
Relative Density. | 1.1676 g/cm3 (Estimated) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 12 mg/mL (35.56 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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