MB076

MB076 is an innovative heterocyclic triazole designed with enhanced plasma stability. It effectively inhibits seven distinct Class C Acinetobacter-derived cephalosporinases (ADCs) β-lactamase variants with K i values less than 1 μM. Additionally, MB076 demonstrates a synergistic effect when combined with various cephalosporins to restore pBCSK(−) susceptibility [1].

Catalog No. T86864Cas No. 2832966-95-5

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MB076

Catalog No. T86864Cas No. 2832966-95-5

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Pack Size	Price	Availability	Quantity
10 mg	Inquiry	10-14 weeks
50 mg	Inquiry	10-14 weeks

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Product Introduction

Bioactivity

Description

In vitro

MB076 (compound B) demonstrates exceptional stability in human plasma at concentrations ranging from 0.5 to 5 μM over 48 hours, with a half-life (t1/2) of 29 hours, significantly exceeding the 9 hours observed for ADC-7/S02030 (PDB4U0X) [1]. Additionally, when combined at a concentration of 10 μg/mL with Ceftazidime (CAZ) and Cefotaxime (CTX) for 48 hours, MB076 synergistically restores drug sensitivity in pBCSK(-) [1]. Cell viability assays [1] conducted in human plasma with concentrations from 0.5 μM to 5 μM and an incubation period of 48 hours further confirm the compound’s outstanding stability.

Chemical Properties

Molecular Weight	373.18
Formula	C₉H₁₂BN₇O₅S₂
Cas No.	2832966-95-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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