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Streptomycin (Agrept) is an aminoglycoside antibiotic derived from Streptomyces, a blocker of stretch-activated and mechanically-sensitive ion channels in neurons and cardiomyocytes, with anti-tuberculosis activity. It strongly binds to nucleic acids, interferes with protein synthesis, and can be used to study Mycobacterium tuberculosis infections.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $30 | In Stock | |
100 mg | $40 | In Stock | |
500 mg | $92 | In Stock |
Description | Streptomycin (Agrept) is an aminoglycoside antibiotic derived from Streptomyces, a blocker of stretch-activated and mechanically-sensitive ion channels in neurons and cardiomyocytes, with anti-tuberculosis activity. It strongly binds to nucleic acids, interferes with protein synthesis, and can be used to study Mycobacterium tuberculosis infections. |
In vitro | Streptomycin is a protein synthesis inhibitor that binds irreversibly to the small 16S rRNA of the 30S ribosome subunit, interfering with the binding of formyl-methionyl-trNA to the 30S subunit. It is often used in combination with penicillin in standard antibiotic mixtures to prevent bacterial infection in cell cultures. [1] |
In vivo | Administration of Streptomycin (644 ± 26 mg/kg/ day) reduced the number of muscle fibers that increased membrane permeability after centrifugal contraction (ECC), but did not improve the degree of fiber swelling in existing EBD-positive fibers. [2] |
Alias | Agrimycin, Agrept |
Molecular Weight | 581.57 |
Formula | C21H39N7O12 |
Cas No. | 57-92-1 |
Smiles | O([C@H]1[C@H](O[C@@H]2[C@@H](NC(=N)N)[C@H](O)[C@@H](NC(=N)N)[C@H](O)[C@H]2O)O[C@@H](C)[C@@]1(C=O)O)[C@H]3[C@@H](NC)[C@H](O)[C@@H](O)[C@H](CO)O3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 160 mg/mL (275.12 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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