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Product Introduction

Bioactivity

Description	Streptomycin sulfate (Phytomycin) is a sulfate salt of streptomycin that is a protein synthesis inhibitor.
In vitro	Strain RB1 exhibits an increased susceptibility to streptomycin that correlates positively with the concentration of CV in the growth medium. Furthermore, as the CV concentration rises, both cytochrome aa3 levels and the bacterium's sensitivity to streptomycin simultaneously escalate. It is noteworthy that cytochrome aa3 plays a critical role in the uptake of streptomycin by B. subtilis[1]. Additionally, streptomycin affects tRNA selection, with resistance mutations predominantly located in protein S12; these mutations are typically associated with enhanced specificity in the tRNA selection process[2].
Alias	Plantomycin, Phytomycin, Estreptomicina

Chemical Properties

Molecular Weight	728.68
Formula	C₂₁H₃₉N₇O₁₂·3/2H₂SO₄
Cas No.	3810-74-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 50 mg/mL (68.61 mM)

DMSO: Insoluble

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.3723 mL	6.8617 mL	13.7234 mL	68.6172 mL
5 mM	0.2745 mL	1.3723 mL	2.7447 mL	13.7234 mL
10 mM	0.1372 mL	0.6862 mL	1.3723 mL	6.8617 mL
20 mM	0.0686 mL	0.3431 mL	0.6862 mL	3.4309 mL
50 mM	0.0274 mL	0.1372 mL	0.2745 mL	1.3723 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

BacterialInhibitorStreptomycin sulfateStreptomycinAntibioticinhibitStreptomycin Sulfate