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Bicyclomycin benzoate

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Catalog No. T10541Cas No. 37134-40-0
Alias FR2054, CS-6253

Bicyclomycin benzoate, an antibiotic, exhibits activity against a broad spectrum of Gram-negative/Gram-positive bacteria.

Bicyclomycin benzoate

Bicyclomycin benzoate

🥰Excellent
Catalog No. T10541Alias FR2054, CS-6253Cas No. 37134-40-0
Bicyclomycin benzoate, an antibiotic, exhibits activity against a broad spectrum of Gram-negative/Gram-positive bacteria.
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Product Introduction

Bioactivity
Description
Bicyclomycin benzoate, an antibiotic, exhibits activity against a broad spectrum of Gram-negative/Gram-positive bacteria.
In vitro
Bicyclomycin interferes with the biosynthesis of lipoprotein and its assembly to peptidoglycan in the cell envelope of E. coli. At the lethal level, Bicyclomycin is shown to inhibit the synthesis of RNA and protein in the growing cells of E. coli 15 THU [1]. Bicyclomycin targets the rho transcription termination factor in Escherichia coli. Bicyclomycin can disrupt the rho molecular machinery thereby leading to a catastrophic effect caused by the untimely overproduction of proteins not normally expressed constitutively, thus leading to a toxic effect on the cells [2]. The inhibition of rho poly(C)-stimulated hydrolysis of ATP by Bicyclomycin has been found to proceed by a non-competitive, reversible pathway with respect to ATP (Ki: 20 μM) [3].
In vivo
Following a single intramuscular administration of Bicyclomycin at a dosage of 50 mg/kg in rats, the compound exhibits a low rate of excretion. It is well distributed across different tissues, with the peak concentration recorded in the kidneys at a level of 100 mg/kg [4].
AliasFR2054, CS-6253
Chemical Properties
Molecular Weight406.39
FormulaC19H22N2O8
Cas No.37134-40-0
Relative Density.1.49 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (246.07 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4607 mL12.3035 mL24.6069 mL123.0345 mL
5 mM0.4921 mL2.4607 mL4.9214 mL24.6069 mL
10 mM0.2461 mL1.2303 mL2.4607 mL12.3035 mL
20 mM0.1230 mL0.6152 mL1.2303 mL6.1517 mL
50 mM0.0492 mL0.2461 mL0.4921 mL2.4607 mL
100 mM0.0246 mL0.1230 mL0.2461 mL1.2303 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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