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Polyketomycin
Catalog No. T12517Cas No. 200625-47-4
Polyketomycin, a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes, exhibits antibacterial, anticancer, and antimalarial activities.
Polyketomycin
Catalog No. T12517Cas No. 200625-47-4
Polyketomycin, a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes, exhibits antibacterial, anticancer, and antimalarial activities.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Polyketomycin, a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes, exhibits antibacterial, anticancer, and antimalarial activities. |
| In vitro | Polyketomycin demonstrates inhibitory activity against a spectrum of cancers, including L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adenocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma, and B16-BL10 melanoma, with respective IC50 values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL, and 1.6 μg/mL[1]. |
| In vivo | In mice, Polyketomycin acute toxicity is estimated to be 6.25-12.5mg/kg[1]. |
| Molecular Weight | 864.84 |
| Formula | C44H48O18 |
| Cas No. | 200625-47-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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