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PNU288034
😃Good
Catalog No. T12512Cas No. 383199-88-0
PNU288034, a potent oxazolidinone antibiotic, demonstrates antimicrobial activity for the prevention and treatment of Gram-negative infections.
PNU288034
😃Good
Purity: 98.41%
Catalog No. T12512Cas No. 383199-88-0
PNU288034, a potent oxazolidinone antibiotic, demonstrates antimicrobial activity for the prevention and treatment of Gram-negative infections.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 665 € | Backorder | |
| 5 mg | 1.710 € | Backorder |
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Purity:98.41%
ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PNU288034, a potent oxazolidinone antibiotic, demonstrates antimicrobial activity for the prevention and treatment of Gram-negative infections. |
| In vitro | In vitro studies, conducted to characterize the involved transporters, demonstrate uptake of PNU-288034 by human organic anion transporter 3 (OAT3; Km = 44 +/- 5 μM) and human multidrug and toxin extrusion protein 1 (hMATE1; Km = 340 +/- 55 μM)[1]. |
| In vivo | In liver microsomes across species, PNU-288034 exhibits metabolic stability, and the unchanged drug is cleared in the urine through an apparent active renal secretion process in rat and monkey. Coadministration of PNU-288034 with the OAT3 inhibitor probenecid significantly increases the plasma area under the curve (170%) and reduces both plasma and renal clearance in monkey. Furthermore, coadministration of PNU-288034 with cimetidine also reduces plasma clearance in rats to a rate comparable to probenecid coadministration[1]. |
| Molecular Weight | 403.4 |
| Formula | C16H19F2N3O5S |
| Cas No. | 383199-88-0 |
| Smiles | O=C1N(C[C@H](CNC(C)=O)O1)C2=CC(F)=C(C(F)=C2)N3CCS(=O)(=O)CC3 |
| Relative Density. | 1.447 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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