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Hypericin
🥰Excellent
Catalog No. T6S0923Cas No. 548-04-9
Alias Hypericine, Cyclosan
Hypericin (Cyclosan) is a natural anthraquinone compound, an extract of Hypericum perforatum, which inhibits PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP, etc. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant activities.
Hypericin
🥰Excellent
Purity: 99.51%
Catalog No. T6S0923Alias Hypericine, CyclosanCas No. 548-04-9
Hypericin (Cyclosan) is a natural anthraquinone compound, an extract of Hypericum perforatum, which inhibits PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP, etc. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant activities.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $52 | In Stock | |
| 5 mg | $129 | In Stock | |
| 10 mg | $192 | In Stock | |
| 25 mg | $379 | In Stock | |
| 50 mg | $559 | In Stock | |
| 100 mg | $783 | In Stock | |
| 500 mg | $1,590 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $143 | In Stock |
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Purity:99.51%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Hypericin (Cyclosan) is a natural anthraquinone compound, an extract of Hypericum perforatum, which inhibits PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP, etc. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant activities. |
| Targets&IC50 | Tyrosine kinase:7.5 μM |
| In vitro | METHODS: Erythrocytes were treated with Bioymifi (10-100 µM) for 24 h. Flow cytometry was used to characterize the hemolytic and bactericidal properties of Bioymifi and the potential molecular mechanisms. RESULTS: Bioymifi exerted a dose-responsive, calcium-independent hemolytic effect, reduced erythrocyte hemoglobin, and significantly increased membrane-bound protein V, Fluo4, and DCF-positive cells, as well as a dual effect on forward and lateral light scattering. [1] METHODS: Neonatal rat ventricular myocytes (nrvm) were treated with Bioymifi (10 µM) for 24 h, and the expression levels of target proteins were detected by Western Blot. RESULTS: The expression of DR5 was higher than that of NRVF in Bioymifi-treated nrvm. [2] |
| In vivo | METHODS: To investigate the role of DR5 activation in the heart, Bioymifi (5 mg/kg/d) micro-osmotic pump was administered to C57BL/6 mice once daily for two weeks. RESULTS: Bioymifi administration resulted in hypertrophy at the level of cardiac organs and cardiomyocytes, but did not affect cardiomyocyte death or cardiac fibrosis. [2] |
| Alias | Hypericine, Cyclosan |
| Molecular Weight | 504.44 |
| Formula | C30H16O8 |
| Cas No. | 548-04-9 |
| Smiles | Cc1cc(O)c2c3c1c1c(C)cc(O)c4c1c1c3c3c(c(O)cc(O)c3c2=O)c2c(O)cc(O)c(c12)c4=O |
| Relative Density. | 1.915 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 5 mg/mL (10 mM), Heating is recommended.  DMSO: 100 mg/mL (37.61 mM), Sonication is recommended. Propylene glycol: 2.52 mg/mL (5.0 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Propylene glycol/Ethanol/DMSO
Ethanol/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
TyrosineKinasesTyrosine Kinasestelomerase and CYPTelomeraseReverse TranscriptaseProtein kinase CPKCmonoaminoxidaseMonoamine OxidasemelanocytesMAOkeratinocytesInhibitorinhibitInfluenzaVirusInfluenza VirusHypericumHypericinfibroblastsDopamine β-monooxygenaseDopamine β-hydroxylaseDopamine beta-monooxygenaseDopamine beta-hydroxylaseCytochrome P450CYPsApoptosisantiviral activityantitumor activityantidepressive activityAntibiotic
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