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5Z-7-Oxozeaenol

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5Z-7-Oxozeaenol

Catalog No. T14055Cas No. 253863-19-3

5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is also an inhibitor of VEGF-R2 with IC50 of 52 nM.

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Pack Size	Price	Availability	Quantity
1 mg	$215	In Stock
5 mg	$748	35 days

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Product Introduction

Bioactivity

Description	5Z-7-Oxozeaenol (FR148083) is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is also an inhibitor of VEGF-R2 with IC50 of 52 nM.
In vitro	5Z-7-Oxozeaenol is a natural anti-protozoan compound from the fungal origin with inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE, and SRC with IC50s of 110, 170, 340, 6300, and 6600 nM, respectively[1]. 5Z-7-Oxozaeenol inhibited PMA-induced AP-1 activity to almost basal levels in KT cells but had no effect on IL-1-induced NF-kB activity in KK cells[2]. 5Z-7-Oxozaeenol inhibits the JNK/p38 pathway, but it is not a direct inhibitor and is signal-specific. 5Z-7-Oxozaeenol prevents inflammation by inhibiting the catalytic activity of the TAK1 MAPK kinase[3].
Alias	FR148083, L783279, LL-Z 1640-2

Chemical Properties

Molecular Weight	362.37
Formula	C19H22O7
Cas No.	253863-19-3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (110.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7596 mL	13.7981 mL	27.5961 mL	137.9805 mL
5 mM	0.5519 mL	2.7596 mL	5.5192 mL	27.5961 mL
10 mM	0.2760 mL	1.3798 mL	2.7596 mL	13.7981 mL
20 mM	0.1380 mL	0.6899 mL	1.3798 mL	6.8990 mL
50 mM	0.0552 mL	0.2760 mL	0.5519 mL	2.7596 mL
100 mM	0.0276 mL	0.1380 mL	0.2760 mL	1.3798 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc