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2-Aminoimidazole
🥰Excellent
Catalog No. T38241Cas No. 7720-39-0
2-Aminoimidazole is a potent antimicrobial agent that effectively targets drug-resistant Mycobacterium tuberculosis by disrupting the proton motive force and blocking the electron transport chain, potentiates the action of beta-lactam antibiotics against Mycobacterium tuberculosis by decreasing the secretion of beta-lactamases and increasing the permeability of cell membranes, activates drug-resistant bacteria and improves therapeutic efficacy.
2-Aminoimidazole
🥰Excellent
Catalog No. T38241Cas No. 7720-39-0
2-Aminoimidazole is a potent antimicrobial agent that effectively targets drug-resistant Mycobacterium tuberculosis by disrupting the proton motive force and blocking the electron transport chain, potentiates the action of beta-lactam antibiotics against Mycobacterium tuberculosis by decreasing the secretion of beta-lactamases and increasing the permeability of cell membranes, activates drug-resistant bacteria and improves therapeutic efficacy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 200 mg | $40 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $40 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 2-Aminoimidazole is a potent antimicrobial agent that effectively targets drug-resistant Mycobacterium tuberculosis by disrupting the proton motive force and blocking the electron transport chain, potentiates the action of beta-lactam antibiotics against Mycobacterium tuberculosis by decreasing the secretion of beta-lactamases and increasing the permeability of cell membranes, activates drug-resistant bacteria and improves therapeutic efficacy. |
| Targets&IC50 | Arginase I (human):3.6 mM (Ki) |
| In vitro | Methods: Acinetobacter baumannii was treated with 2-Aminoimidazole (100 μM, 30 minutes) and live samples were observed after 30 minutes of incubation. Results: The fluorescein signal in live Acinetobacter baumannii samples was evenly distributed throughout the cell, with hot spots appearing within the cell boundaries. 2-Aminoimidazole can penetrate the membrane barrier. [1] |
| Molecular Weight | 83.09 |
| Formula | C3H5N3 |
| Cas No. | 7720-39-0 |
| Smiles | Nc1ncc[nH]1 |
| Relative Density. | 1.313 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight | store at 4°C | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (962.81 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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