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Cefoxitin

Cefoxitin
Cefoxitin (Rephoxitin) is a broad-spectrum, orally available second-generation cephalosporins antibiotic. Cefoxitin interferes with the synthesis of bacterial cell walls. Its activity profile includes Gram-negative and Gram-positive bacteria, and is commonly used in abdominal cavity infections, pelvic infections, and certain types of gynecological infections, and is highly effective against anaerobic bacteria.
Catalog No. T20643Cas No. 35607-66-0
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Purity:99.8%
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Cefoxitin

Catalog No. T20643Alias Rephoxitin, CefoxitinumCas No. 35607-66-0

Cefoxitin (Rephoxitin) is a broad-spectrum, orally available second-generation cephalosporins antibiotic. Cefoxitin interferes with the synthesis of bacterial cell walls. Its activity profile includes Gram-negative and Gram-positive bacteria, and is commonly used in abdominal cavity infections, pelvic infections, and certain types of gynecological infections, and is highly effective against anaerobic bacteria.
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500 mg$967-10 days
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Product Introduction

Bioactivity
Description
Cefoxitin (Rephoxitin) is a broad-spectrum, orally available second-generation cephalosporins antibiotic. Cefoxitin interferes with the synthesis of bacterial cell walls. Its activity profile includes Gram-negative and Gram-positive bacteria, and is commonly used in abdominal cavity infections, pelvic infections, and certain types of gynecological infections, and is highly effective against anaerobic bacteria.
Targets&IC50
PBP2a:0.72 μg/mL, PBP5:0.19 μg/mL, PBP3:1.04 μg/mL, PBP2b:0.19 μg/mL, PBP4:0.14 μg/mL
In vitro
Cefoxitin demonstrates effective antimicrobial properties against Gram-positive bacteria, with minimum inhibitory concentrations (MICs) spanning from 1-6 μg/mL for various Gram-positive pathogens[1]. Furthermore, at a concentration of 1.25 µM/mL, Cefoxitin exhibits potent bactericidal activity against B. burgdorferi[2].
In vivo
Cefoxitin administration at a dose of 20 mg/kg via intraperitoneal injection for 5 consecutive days demonstrates effective eradication of B. burgdorferi in the C3H/HeN mouse model.[2]
AliasRephoxitin, Cefoxitinum
Chemical Properties
Molecular Weight427.45
FormulaC16H17N3O7S2
Cas No.35607-66-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90.0 mg/mL (210.6 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3395 mL11.6973 mL23.3945 mL116.9727 mL
5 mM0.4679 mL2.3395 mL4.6789 mL23.3945 mL
10 mM0.2339 mL1.1697 mL2.3395 mL11.6973 mL
20 mM0.1170 mL0.5849 mL1.1697 mL5.8486 mL
50 mM0.0468 mL0.2339 mL0.4679 mL2.3395 mL
100 mM0.0234 mL0.1170 mL0.2339 mL1.1697 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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