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Cefoxitin (Rephoxitin) is a broad-spectrum, orally available second-generation cephalosporins antibiotic. Cefoxitin interferes with the synthesis of bacterial cell walls. Its activity profile includes Gram-negative and Gram-positive bacteria, and is commonly used in abdominal cavity infections, pelvic infections, and certain types of gynecological infections, and is highly effective against anaerobic bacteria.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $96 | 7-10 days |
Description | Cefoxitin (Rephoxitin) is a broad-spectrum, orally available second-generation cephalosporins antibiotic. Cefoxitin interferes with the synthesis of bacterial cell walls. Its activity profile includes Gram-negative and Gram-positive bacteria, and is commonly used in abdominal cavity infections, pelvic infections, and certain types of gynecological infections, and is highly effective against anaerobic bacteria. |
Targets&IC50 | PBP2a:0.72 μg/mL, PBP5:0.19 μg/mL, PBP3:1.04 μg/mL, PBP2b:0.19 μg/mL, PBP4:0.14 μg/mL |
In vitro | Cefoxitin demonstrates effective antimicrobial properties against Gram-positive bacteria, with minimum inhibitory concentrations (MICs) spanning from 1-6 μg/mL for various Gram-positive pathogens[1]. Furthermore, at a concentration of 1.25 µM/mL, Cefoxitin exhibits potent bactericidal activity against B. burgdorferi[2]. |
In vivo | Cefoxitin administration at a dose of 20 mg/kg via intraperitoneal injection for 5 consecutive days demonstrates effective eradication of B. burgdorferi in the C3H/HeN mouse model.[2] |
Alias | Rephoxitin, Cefoxitinum |
Molecular Weight | 427.45 |
Formula | C16H17N3O7S2 |
Cas No. | 35607-66-0 |
Smiles | [H][C@]12SCC(COC(N)=O)=C(N1C(=O)[C@]2(NC(=O)Cc1cccs1)OC)C(O)=O |
Relative Density. | 1.63 g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90.0 mg/mL (210.6 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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