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Zanamivir
Catalog No. T2529Cas No. 139110-80-8
Alias GG167
Zanamivir (GG167) is a guanido-neuraminic acid that is used to inhibit NEURAMINIDASE.
Zanamivir
Catalog No. T2529Alias GG167Cas No. 139110-80-8
Zanamivir (GG167) is a guanido-neuraminic acid that is used to inhibit NEURAMINIDASE.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $45 | In Stock | |
| 10 mg | $72 | In Stock | |
| 25 mg | $112 | In Stock | |
| 50 mg | $157 | In Stock | |
| 100 mg | $273 | In Stock | |
| 200 mg | $397 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $56 | In Stock |
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Purity:99.98%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Zanamivir (GG167) is a guanido-neuraminic acid that is used to inhibit NEURAMINIDASE. |
| Targets&IC50 | Influenza A:0.95 nM, Influenza B:2.7 nM |
| In vitro | Zanamivir reduces pulmonary viral titers and decreases morbidity and mortality rates in a lethal murine model infected with the virus. |
| In vivo | Zanamivir effectively reduces viral replication in vitro by inhibiting the influenza neuraminidase and preventing the cleavage of sialic acid residues. This interference blocks the spread of progeny viruses in mucosal secretions and lowers viral infectivity. Furthermore, Zanamivir diminishes the area of plaques formed by neuraminidase-deficient mutants, indicating that its action in disrupting cell-cell fusion is independent of its neuraminidase inhibition activity. The compound also prevents the adhesion and fusion of persistently infected cells with uninfected erythrocytes. Assessment through lipid mixing and content mixing reveals that Zanamivir does not affect erythrocyte adhesion but does inhibit HA2b-red blood cell fusion. Additionally, Zanamivir leads to decreased sensitivity in influenza A/H1N1 variants His274Asn, His274 gly, His274Ser, and His274 gln. |
| Alias | GG167 |
| Molecular Weight | 332.31 |
| Formula | C12H20N4O7 |
| Cas No. | 139110-80-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | H2O: 10 mg/mL (30.09 mM), Sonication and heating are recommended.  DMSO: <1 mg/mL (Insoluble) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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