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Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic derived from tetracycline that binds to the 30S ribosomal subunit, disrupting the binding of aminoacyl-tRNA to the mRNA-ribosome complex.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $32 | In Stock | |
10 mg | $52 | In Stock | |
25 mg | $72 | In Stock | |
50 mg | $107 | In Stock | |
100 mg | $171 | In Stock | |
200 mg | $261 | In Stock | |
500 mg | $439 | In Stock | |
1 mL x 10 mM (in DMSO) | $54 | In Stock |
Description | Tigecycline (GAR-936) is a broad-spectrum glycylcycline antibiotic derived from tetracycline that binds to the 30S ribosomal subunit, disrupting the binding of aminoacyl-tRNA to the mRNA-ribosome complex. |
Targets&IC50 | E. coli:125 ng/mL (Mean MIC), A. baumannii:1 mg/mL (MIC50), A. baumannii:2 mg/mL (MIC90) |
In vitro | Tigecycline inhibited methicillin-resistant Staphylococcus aureus in a rabbit model of osteomyelitis. Tigecycline was shown to be resistant to Legionella pneumophila in guinea pigs with Legionella pneumophila pneumonia. |
In vivo | Tigecycline, a substrate for the tetracycline-specific efflux pump, exhibits antibacterial activity against a wide range of aerobic and anaerobic bacteria. For enterococci, staphylococci and streptococci (MIC=0.06-0.25 mg / L), Tigecycline was able to produce bacteriostatic effects. |
Alias | GAR-936 |
Molecular Weight | 585.65 |
Formula | C29H39N5O8 |
Cas No. | 220620-09-7 |
Smiles | O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C(C3)=C(N(C)C)C=C(NC(CNC(C)(C)C)=O)C4O)[H])[H] |
Relative Density. | 1.455 g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 93 mg/mL (158.8 mM) H2O: 92 mg/mL (157.1 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
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