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Cycloheximide
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Catalog No. T1225Cas No. 66-81-9
Alias Naramycin A, Actidione
Cycloheximide (Naramycin A) is a natural product that reversibly inhibits translation elongation, is an antimitotic compound, and is an inhibitor of DNA and protein synthesis.
Cycloheximide
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Purity: 99.10%
Catalog No. T1225Alias Naramycin A, ActidioneCas No. 66-81-9
Cycloheximide (Naramycin A) is a natural product that reversibly inhibits translation elongation, is an antimitotic compound, and is an inhibitor of DNA and protein synthesis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 200 mg | $71 | In Stock | |
| 500 mg | $142 | In Stock |
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Purity:99.10%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | Cycloheximide (Naramycin A) is a natural product that reversibly inhibits translation elongation, is an antimitotic compound, and is an inhibitor of DNA and protein synthesis. |
| Targets&IC50 | Protein biosynthesis:532.5 nM. |
| In vitro | Cycloheximide is used for inhibiting protein synthesis. Cycloheximide has shown that it can block the extension of the nuclear translation. Cycloheximide binds to the nucleus and inhibit EEF2 -mediated transliteration. [1] |
| In vivo | Before training with 200 μA electric shock, mice were injected at 30, 60, or 120 mg/kg Cycloheximide. Cycloheximide has a significant impact on the incubation period of memory testing. In the control group, the delay of the test is significantly higher than the delay in training. The lowest dose of Cycloheximide test, 30 mg/kg, resulting in the incubation period of the test significantly higher than the control group. Accepting two higher doses of Cycloheximide, any kind of mice in the test are equivalent to the control group, the higher doses nor damage the memory under these conditions, resulting in the inverted U -shaped dose reaction curve. [2] |
| Alias | Naramycin A, Actidione |
| Molecular Weight | 281.35 |
| Formula | C15H23NO4 |
| Cas No. | 66-81-9 |
| Smiles | [C@H](CC1CC(=O)NC(=O)C1)(O)[C@]2(C(=O)[C@@H](C)C[C@H](C)C2)[H] |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL(284.34 mM), Sonication is recommended. H2O: 15 mg/mL(53.31 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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