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Borrelidin

Borrelidin (Treponemycin) is a macrolide antibiotic isolated from *Streptomyces rochei*, acting as a threonyl-tRNA synthetase inhibitor in both bacterial and eukaryal systems.

Catalog No. T10582Cas No. 7184-60-3

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Borrelidin

Catalog No. T10582Cas No. 7184-60-3

Borrelidin (Treponemycin) is a macrolide antibiotic isolated from *Streptomyces rochei*, acting as a threonyl-tRNA synthetase inhibitor in both bacterial and eukaryal systems.

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Pack Size	Price	Availability	Quantity
500 μg	$198	35 days
1 mg	$297	35 days

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Product Introduction

Bioactivity

Description	Borrelidin (Treponemycin) is a macrolide antibiotic isolated from Streptomyces rochei, acting as a threonyl-tRNA synthetase inhibitor in both bacterial and eukaryal systems.
Targets&IC50	CDC28-Cln2:24 μM
In vitro	Borrelidin is an inhibitor of Cdc28/Cln2 of the budding yeast (IC50: 24 μM) [2]. Borrelidin is a potent angiogenesis inhibitor (IC50: 0.8 nM) and induces apoptosis of the tube-forming cells. Borrelidin has strong antimalarial activities (IC50s: 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum) [3].
Alias	Treponemycin

Chemical Properties

Molecular Weight	489.64
Formula	C₂₈H₄₃NO₆
Cas No.	7184-60-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 100 mg/mL (204.23 mM)

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.0423 mL	10.2116 mL	20.4232 mL	102.1158 mL
5 mM	0.4085 mL	2.0423 mL	4.0846 mL	20.4232 mL
10 mM	0.2042 mL	1.0212 mL	2.0423 mL	10.2116 mL
20 mM	0.1021 mL	0.5106 mL	1.0212 mL	5.1058 mL
50 mM	0.0408 mL	0.2042 mL	0.4085 mL	2.0423 mL
100 mM	0.0204 mL	0.1021 mL	0.2042 mL	1.0212 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Borrelidin