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Borrelidin
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Catalog No. T10582Cas No. 7184-60-3
Alias Treponemycin
Borrelidin (Treponemycin) is a nitrogen-containing macrolide antibiotic isolated from Streptomyces rochei, which inhibits sugar-acyl-tRNA synthetase. It exhibits anticancer, antifungal, and anti-angiogenesis activities, inhibiting tumor growth and lung metastasis.
Borrelidin
😃Good
Catalog No. T10582Alias TreponemycinCas No. 7184-60-3
Borrelidin (Treponemycin) is a nitrogen-containing macrolide antibiotic isolated from Streptomyces rochei, which inhibits sugar-acyl-tRNA synthetase. It exhibits anticancer, antifungal, and anti-angiogenesis activities, inhibiting tumor growth and lung metastasis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | $198 | 35 days | |
| 1 mg | $297 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Borrelidin (Treponemycin) is a nitrogen-containing macrolide antibiotic isolated from Streptomyces rochei, which inhibits sugar-acyl-tRNA synthetase. It exhibits anticancer, antifungal, and anti-angiogenesis activities, inhibiting tumor growth and lung metastasis. |
| Targets&IC50 | CDC28-Cln2:24 μM |
| In vitro | Borrelidin can effectively inhibit the proliferation of ALL cell lines with a maximum 50% inhibitory concentration of 50 ng/mL. [1] The 50% inhibitory concentration (IC50) of Borrelidin for Cdc28/Cln2 was 24 μM. Borrelidin is a potent angiogenesis inhibitor with an IC50 value of 0.8 nM that induces apoptosis in angioforming cells. [3] Borrelidin showed highly selective cytotoxicity to cancer cells and endothelial cell subpopulations. [4] |
| In vivo | Borrelidin (0.25 mg/kg intraperitoneally injected) in combination with fumagilin increased antimalarial activity in Plasmodium berghei-infected mice. [5] |
| Alias | Treponemycin |
| Molecular Weight | 489.64 |
| Formula | C28H43NO6 |
| Cas No. | 7184-60-3 |
| Smiles | C[C@H]1C[C@H](C[C@@H]([C@H](/C(=C\C=C\C[C@H](OC(=O)C[C@@H]([C@H](C1)C)O)[C@@H]2CCC[C@H]2C(=O)O)/C#N)O)C)C |
| Relative Density. | 1.1362 g/cm3 (Estimated) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 100 mg/mL (204.23 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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