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MMRi64

Catalog No. T28078Cas No. 430458-66-5

MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cells, disrupts Mdm2-MdmX interactions, and downregulates Mdm2 and MdmX in leukemia cells.MMRi64 MMRi64 can be used in cancer research.

MMRi64

MMRi64

Purity: 99.61%
Catalog No. T28078Cas No. 430458-66-5
MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cells, disrupts Mdm2-MdmX interactions, and downregulates Mdm2 and MdmX in leukemia cells.MMRi64 MMRi64 can be used in cancer research.
Pack SizePriceAvailabilityQuantity
1 mg$51In Stock
5 mg$122In Stock
10 mg$193In Stock
25 mg$333In Stock
50 mg$497In Stock
100 mg$693In Stock
500 mg$1,450In Stock
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Purity:99.61%
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Product Introduction

Bioactivity
Description
MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity.MMRi64 potently induces p53 accumulation and apoptosis in the p53 pathway in leukemia/lymphoma cells, disrupts Mdm2-MdmX interactions, and downregulates Mdm2 and MdmX in leukemia cells.MMRi64 MMRi64 can be used in cancer research.
Chemical Properties
Molecular Weight410.3
FormulaC22H17Cl2N3O
Cas No.430458-66-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/mL (146.23 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4372 mL12.1862 mL24.3724 mL121.8621 mL
5 mM0.4874 mL2.4372 mL4.8745 mL24.3724 mL
10 mM0.2437 mL1.2186 mL2.4372 mL12.1862 mL
20 mM0.1219 mL0.6093 mL1.2186 mL6.0931 mL
50 mM0.0487 mL0.2437 mL0.4874 mL2.4372 mL
100 mM0.0244 mL0.1219 mL0.2437 mL1.2186 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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