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NSC59984

🥰Excellent
Catalog No. T6910Cas No. 803647-40-7

NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.

NSC59984

NSC59984

🥰Excellent
Purity: 99.39%
Catalog No. T6910Cas No. 803647-40-7
NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.
Pack SizePriceAvailabilityQuantity
5 mg$64In Stock
10 mg$109In Stock
25 mg$228In Stock
50 mg$372In Stock
100 mg$597In Stock
500 mg$1,260In Stock
1 mL x 10 mM (in DMSO)$70In Stock
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Purity:99.39%
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Product Introduction

Bioactivity
Description
NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.
In vitro
NSC59984 selectively reactivates the p53 pathway and induces p73-dependent cell death in mutant p53-expressing human colorectal cancer cells. It also promotes cell death in various cancer cell lines with different p53 mutations, showing minimal genotoxicity in normal cells. [1]
In vivo
In nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner. [1]
Cell Research
Cells are seeded at 5,000 cells per well on 96-well plates. Cells are mixed with an equal volume of CellTiter-Glo reagents, following the manufacturer's protocol, and bioluminescence imaging is measured using the IVIS imager.(Only for Reference)
Chemical Properties
Molecular Weight265.27
FormulaC12H15N3O4
Cas No.803647-40-7
SmilesCN1CCN(CC1)C(=O)\C=C\c1ccc(o1)[N+]([O-])=O
Relative Density.1.304 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 49 mg/mL (184.7 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 55 mg/mL (207.34 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.7697 mL18.8487 mL37.6974 mL188.4872 mL
5 mM0.7539 mL3.7697 mL7.5395 mL37.6974 mL
10 mM0.3770 mL1.8849 mL3.7697 mL18.8487 mL
20 mM0.1885 mL0.9424 mL1.8849 mL9.4244 mL
50 mM0.0754 mL0.3770 mL0.7539 mL3.7697 mL
100 mM0.0377 mL0.1885 mL0.3770 mL1.8849 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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2 Enter the in vivo formulation:
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