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NSC59984

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Purity:99.39%

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COA HNMR HPLC

NSC59984

Catalog No. T6910Cas No. 803647-40-7

NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.

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Pack Size	Price	Availability
5 mg	$64	In Stock
10 mg	$109	In Stock
25 mg	$228	In Stock
50 mg	$372	In Stock
100 mg	$597	In Stock
500 mg	$1,260	In Stock
1 mL x 10 mM (in DMSO)	$70	In Stock

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Product Introduction

Bioactivity

Description	NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.
In vitro	NSC59984 selectively reactivates the p53 pathway and induces p73-dependent cell death in mutant p53-expressing human colorectal cancer cells. It also promotes cell death in various cancer cell lines with different p53 mutations, showing minimal genotoxicity in normal cells. [1]
In vivo	In nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner. [1]
Cell Research	Cells are seeded at 5,000 cells per well on 96-well plates. Cells are mixed with an equal volume of CellTiter-Glo reagents, following the manufacturer's protocol, and bioluminescence imaging is measured using the IVIS imager.(Only for Reference)

Chemical Properties

Molecular Weight	265.27
Formula	C12H15N3O4
Cas No.	803647-40-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 49 mg/mL (184.7 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 55 mg/mL (207.34 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7697 mL	18.8487 mL	37.6974 mL	188.4872 mL
5 mM	0.7539 mL	3.7697 mL	7.5395 mL	37.6974 mL
10 mM	0.3770 mL	1.8849 mL	3.7697 mL	18.8487 mL
20 mM	0.1885 mL	0.9424 mL	1.8849 mL	9.4244 mL
50 mM	0.0754 mL	0.3770 mL	0.7539 mL	3.7697 mL
100 mM	0.0377 mL	0.1885 mL	0.3770 mL	1.8849 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc