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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $64 | In Stock | |
10 mg | $109 | In Stock | |
25 mg | $228 | In Stock | |
50 mg | $372 | In Stock | |
100 mg | $597 | In Stock | |
500 mg | $1,260 | In Stock | |
1 mL x 10 mM (in DMSO) | $70 | In Stock |
Description | NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation. |
In vitro | NSC59984 selectively reactivates the p53 pathway and induces p73-dependent cell death in mutant p53-expressing human colorectal cancer cells. It also promotes cell death in various cancer cell lines with different p53 mutations, showing minimal genotoxicity in normal cells. [1] |
In vivo | In nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner. [1] |
Cell Research | Cells are seeded at 5,000 cells per well on 96-well plates. Cells are mixed with an equal volume of CellTiter-Glo reagents, following the manufacturer's protocol, and bioluminescence imaging is measured using the IVIS imager.(Only for Reference) |
Molecular Weight | 265.27 |
Formula | C12H15N3O4 |
Cas No. | 803647-40-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 49 mg/mL (184.7 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 55 mg/mL (207.34 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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