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Amifostine thiol

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Amifostine thiol

Catalog No. T37538Cas No. 31098-42-7

Amifostine thiol (WR-1065) is a radioprotectant that protects DNA from fast neutron-induced strand breaks.Amifostine thiol ameliorates (P<0.001) 6-OHDA-induced stiffness in a dose-dependent manner and activates p53 through a JNK-dependent signaling pathway.

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Pack Size	Price	Availability	Quantity
2 mg	$30	In Stock

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Product Introduction

Bioactivity

Description	Amifostine thiol (WR-1065) is a radioprotectant that protects DNA from fast neutron-induced strand breaks.Amifostine thiol ameliorates (P<0.001) 6-OHDA-induced stiffness in a dose-dependent manner and activates p53 through a JNK-dependent signaling pathway.
In vitro	4 mM Amifostine thiol exhibits a protective effect against the genome instability induced by 30 minutes of X-ray irradiation, and also protects RKO36 cells from chromosomal damage and death caused by ionizing radiation[1].
Alias	WR-1065

Chemical Properties

Molecular Weight	134.24
Formula	C5H14N2S
Cas No.	31098-42-7

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 80 mg/mL (595.9 mM), Sonication is recommended.

DMSO: 200 mg/mL (1.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	7.4493 mL	37.2467 mL	74.4934 mL	372.4672 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	1.4899 mL	7.4493 mL	14.8987 mL	74.4934 mL
10 mM	0.7449 mL	3.7247 mL	7.4493 mL	37.2467 mL
20 mM	0.3725 mL	1.8623 mL	3.7247 mL	18.6234 mL
50 mM	0.1490 mL	0.7449 mL	1.4899 mL	7.4493 mL
100 mM	0.0745 mL	0.3725 mL	0.7449 mL	3.7247 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc