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HBX 41108

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Catalog No. T21527Cas No. 924296-39-9
Alias HBX-41108

HBX 41108 (HBX-41108) is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBX 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM.

HBX 41108

HBX 41108

🥰Excellent
Purity: 95.63%
Catalog No. T21527Alias HBX-41108Cas No. 924296-39-9
HBX 41108 (HBX-41108) is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBX 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM.
Pack SizePriceAvailabilityQuantity
1 mg$47In Stock
2 mg$68In Stock
5 mg$113In Stock
10 mg$189In Stock
25 mg$447In Stock
50 mg$659In Stock
100 mg$939In Stock
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Purity:95.63%
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Product Introduction

Bioactivity
Description
HBX 41108 (HBX-41108) is a non-competitive, reversible inhibitor of USP7 with an IC50 of 424nM. HBX 41108 inhibited deubiquitination of p53 mediated by USP7 in a dose-dependent manner with an IC50 of 0.8μM.
Targets&IC50
p53:0.8μM, USP7:424nM
AliasHBX-41108
Chemical Properties
Molecular Weight266.64
FormulaC13H3ClN4O
Cas No.924296-39-9
SmilesClc1ccc-2c(c1)C(=O)c1nc(C#N)c(nc-21)C#N
Relative Density.1.66 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/mL (225.02 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7504 mL18.7519 mL37.5038 mL187.5188 mL
5 mM0.7501 mL3.7504 mL7.5008 mL37.5038 mL
10 mM0.3750 mL1.8752 mL3.7504 mL18.7519 mL
20 mM0.1875 mL0.9376 mL1.8752 mL9.3759 mL
50 mM0.0750 mL0.3750 mL0.7501 mL3.7504 mL
100 mM0.0375 mL0.1875 mL0.3750 mL1.8752 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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