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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $106 | In Stock | |
5 mg | $346 | In Stock | |
10 mg | $499 | In Stock | |
25 mg | $762 | In Stock | |
50 mg | $987 | In Stock | |
100 mg | $1,370 | In Stock | |
500 mg | $2,770 | In Stock | |
1 mL x 10 mM (in DMSO) | $391 | In Stock |
Description | RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively). |
Targets&IC50 | p53-MDM2:~17 nM, p53-MDMX:~24 nM |
In vitro | RO-5963 (10 μM, 24 hours) potently activates p53 and elevates p21 and MDM2 levels. RO-5963 (10-20 μM; 48 hours) displays much higher apoptotic activity than Nutlin in both MCF7 and ZR75-30 cell lines [1]. |
Molecular Weight | 518.9 |
Formula | C24H21ClF2N4O5 |
Cas No. | 1416663-77-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (96.36 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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